T
Takuya Kitamoto
Researcher at University of Tokyo
Publications - 9
Citations - 2436
Takuya Kitamoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Retinoid X receptor & Retinoic acid. The author has an hindex of 7, co-authored 9 publications receiving 2371 citations. Previous affiliations of Takuya Kitamoto include Tokyo University of Agriculture.
Papers
More filters
Journal ArticleDOI
Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
Shigeaki Kato,Hideki Endoh,Yoshikazu Masuhiro,Takuya Kitamoto,Shimami Uchiyama,Haruna Sasaki,Shoichi Masushige,Yukiko Gotoh,Eisuke Nishida,Hiroyuki Kawashima,Daniel Metzger,Pierre Chambon +11 more
TL;DR: The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1), which is modulated by the phosphorylated Ser118 through the Ras-MAPK cascade of the growth factor signaling pathways.
Journal ArticleDOI
p300 Mediates Functional Synergism between AF-1 and AF-2 of Estrogen Receptor α and β by Interacting Directly with the N-terminal A/B Domains
Yoko Kobayashi,Takuya Kitamoto,Yoshikazu Masuhiro,Michiko Watanabe,Toshiya Kase,Daniel Metzger,Junn Yanagisawa,Shigeaki Kato +7 more
TL;DR: Findings indicate that ligand-induced functional synergism between AF-1 and AF-2 is mediated through p300 by its direct binding to the A/B regions of ERα and ERβ.
Journal ArticleDOI
Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway.
Kanae Ebihara,Yoshikazu Masuhiro,Takuya Kitamoto,Miyuki Suzawa,Yoshikatsu Uematsu,Tatsuya Yoshizawa,Toshio Ono,Hideyuki Harada,Koichiro Matsuda,Tadao Hasegawa,Shoichi Masushige,Shigeaki Kato +11 more
TL;DR: The present study indicates that this new VDR isoform negatively modulates the vitamin D signaling pathway, through a particular set of target genes.
Journal ArticleDOI
Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-β mediated fibrogenesis in vivo
Masataka Okuno,Takashi Sato,Takashi Sato,Takuya Kitamoto,Takuya Kitamoto,Shoko Imai,Norifumi Kawada,Yasuhiro Suzuki,Hiroyuki Yoshimura,Hisataka Moriwaki,Kaori Onuki,Shoichi Masushige,Yasutoshi Muto,Scott L. Friedman,Shigeaki Kato,Soichi Kojima +15 more
TL;DR: Findings suggest a potential link between 9,13-di-cis RA formation and hepatic fibrosis via formation of TGF-beta in vivo, and thus provide further insight into the biologic role of retinoids during hepatic Fibrogenesis.
Journal ArticleDOI
Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton
Hiroyuki Miyachi,Akihiko Azuma,Takuya Kitamoto,Kozue Hayashi,Shigeaki Kato,Masafumi Koga,Bunzo Sato,Yuichi Hashimoto +7 more
TL;DR: Anti-androgenic activity of various phthalimide analogs was evaluated based on inhibition of androgen-induced activation of nuclear androgen receptor (CAT assay) and on growth inhibition of the androgens-dependent clonal cell line SC-3.