T
Tale Barøy
Researcher at Oslo University Hospital
Publications - 6
Citations - 437
Tale Barøy is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Regulation of gene expression & Osteosarcoma. The author has an hindex of 6, co-authored 6 publications receiving 383 citations. Previous affiliations of Tale Barøy include University of Oslo.
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Journal ArticleDOI
Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs
Heidi M. Namløs,Leonardo A. Meza-Zepeda,Leonardo A. Meza-Zepeda,Tale Barøy,Ingrid H.G. Østensen,Stine H. Kresse,Marieke L. Kuijjer,Massimo Serra,Horst Bürger,Anne-Marie Cleton-Jansen,Ola Myklebost,Ola Myklebost +11 more
TL;DR: This study provides an integrated analysis of miRNA and mRNA in osteosarcoma, and gives new insight into the complex genetic mechanisms of osteosARcoma development and progression, as well as identifying 177 miRNAs that were differentially expressed in osteOSarcomA cell lines relative to normal bone.
Journal ArticleDOI
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
Susanne Lorenz,Tale Barøy,Tale Barøy,Jinchang Sun,Torfinn Nome,Daniel Vodak,Jan Christian Bryne,Anne Mari Håkelien,Lynnette Fernandez-Cuesta,Birte Möhlendick,Harald Rieder,Karoly Szuhai,Olga Zaikova,Terje Cruickshank Ahlquist,Terje Cruickshank Ahlquist,Gard O. S. Thomassen,Gard O. S. Thomassen,Rolf Inge Skotheim,Rolf Inge Skotheim,Ragnhild A. Lothe,Ragnhild A. Lothe,Patrick S. Tarpey,Peter J. Campbell,Adrienne M. Flanagan,Ola Myklebost,Leonardo A. Meza-Zepeda +25 more
TL;DR: TP53 rearrangements are the major mechanism of p53 inactivation in osteosarcoma, and together with active MMBIR and MMEJ, this inactivation probably contributes to the exceptional chromosomal instability in these tumors.
Journal ArticleDOI
Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor.
Heidi M. Namløs,Kjetil Boye,Skyler Mishkin,Tale Barøy,Susanne Lorenz,Bodil Bjerkehagen,Eva W. Stratford,Else Munthe,Brian Kudlow,Ola Myklebost,Ola Myklebost,Leonardo A. Meza-Zepeda +11 more
TL;DR: It is shown that detection of GIST-specific mutations in plasma is particularly feasible for patients with high tumor burden, and mutational analysis by use of liquid biopsies can capture the molecular heterogeneity of the whole tumor, and may guide treatment decisions during progression.
Journal ArticleDOI
Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
Tale Barøy,Stine H. Kresse,Magne Skårn,Marianne Stabell,Russell Castro,Silje Ugland Lauvrak,Antonio Llombart-Bosch,Ola Myklebost,Ola Myklebost,Leonardo A. Meza-Zepeda +9 more
TL;DR: The high frequency and the specificity of the deletion indicate that it is important for the development of osteosarcomas, and the tumor suppressor function of LSAMP is likely exerted by reducing the proliferation rate of the tumor cells.
Journal ArticleDOI
Epigenetic Regulation and Functional Characterization of MicroRNA-142 in Mesenchymal Cells
TL;DR: It is shown that treatment with the demethylating agent 5-Aza-2′-deoxycytidine significantly reduced the DNA methylation of the upstream CpG island, which led to increased expression, and that in vitro DNA methylations of the downstream region of the mir-142 precursor repressed its transcriptional activity.