Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs
Heidi M. Namløs,Leonardo A. Meza-Zepeda,Leonardo A. Meza-Zepeda,Tale Barøy,Ingrid H.G. Østensen,Stine H. Kresse,Marieke L. Kuijjer,Massimo Serra,Horst Bürger,Anne-Marie Cleton-Jansen,Ola Myklebost,Ola Myklebost +11 more
TLDR
This study provides an integrated analysis of miRNA and mRNA in osteosarcoma, and gives new insight into the complex genetic mechanisms of osteosARcoma development and progression, as well as identifying 177 miRNAs that were differentially expressed in osteOSarcomA cell lines relative to normal bone.Abstract:
Background
Osteosarcomas are the most common primary malignant tumors of bone and show multiple and complex genomic aberrations miRNAs are non-coding RNAs capable of regulating gene expression at the post transcriptional level, and miRNAs and their target genes may represent novel therapeutic targets or biomarkers for osteosarcoma In order to investigate the involvement of miRNAs in osteosarcoma development, global microarray analyses of a panel of 19 human osteosarcoma cell lines was performedread more
Citations
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Atlas of Genetics and Cytogenetics in Oncology and Haematology
TL;DR: WWTR1 (also called TAZ in publications) is a WW domaing-containing transcriptional coactivator, which was first identified as a 14-3-3 binding protein that is involved in mesenchymal stem cell differentiation as well as tumorigenesis.
Journal ArticleDOI
Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
Silje Ugland Lauvrak,Else Munthe,Stine H. Kresse,Eva W. Stratford,Heidi M. Namløs,Leonardo A. Meza-Zepeda,Ola Myklebost,Ola Myklebost +7 more
TL;DR: For the first time, expression profiles are associated with functional characteristics of osteosarcoma cell lines, and the differentially expressed mRNAs and miRNAs identified in this study may represent good candidates for future therapeutic targets.
Journal ArticleDOI
Diverse roles of miR-29 in cancer (Review)
TL;DR: As a tumor suppressor, miR-29 restrains cancer progression by promoting tumor cell apoptosis, by suppressing DNA methylation of tumor-suppressor genes, by reducing proliferation of tumors and by increasing chemosensitivity, while as a tumor promoter, mi R-29 mediates epithelial-mesenchymal transition (EMT) and promotes metastasis in breast cancer and colon cancer.
Journal ArticleDOI
MicroRNAs and Potential Targets in Osteosarcoma: Review
TL;DR: It is suggested a global approach to the understanding of the pathogenesis of osteosarcoma may identify candidate miRNAs as promising biomarkers for this rare disease.
References
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
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Bioconductor: open software development for computational biology and bioinformatics
Robert Gentleman,Vincent J. Carey,Douglas M. Bates,Benjamin M. Bolstad,Marcel Dettling,Sandrine Dudoit,Byron Ellis,Laurent Gautier,Yongchao Ge,Jeff Gentry,Kurt Hornik,Torsten Hothorn,Wolfgang Huber,Stefano Maria Iacus,Rafael A. Irizarry,Friedrich Leisch,Cheng Li,Martin Maechler,A. J. Rossini,Günther Sawitzki,Colin A. Smith,Gordon K. Smyth,Luke Tierney,Jean Yang,Jianhua Zhang +24 more
TL;DR: Details of the aims and methods of Bioconductor, the collaborative creation of extensible software for computational biology and bioinformatics, and current challenges are described.
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MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
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Most mammalian mRNAs are conserved targets of microRNAs
TL;DR: This work overhauled its tool for finding preferential conservation of sequence motifs and applied it to the analysis of human 3'UTRs, increasing by nearly threefold the detected number of preferentially conserved miRNA target sites.
Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.