L
Lynnette Fernandez-Cuesta
Researcher at International Agency for Research on Cancer
Publications - 61
Citations - 6619
Lynnette Fernandez-Cuesta is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 26, co-authored 47 publications receiving 5039 citations. Previous affiliations of Lynnette Fernandez-Cuesta include University of Cologne & Max Planck Society.
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Journal ArticleDOI
Comprehensive genomic profiles of small cell lung cancer
Julie George,Jing Shan Lim,Se Jin Jang,Yupeng Cun,Luka Ozretić,Gu Kong,Frauke Leenders,Xin Lu,Lynnette Fernandez-Cuesta,Graziella Bosco,Christian Müller,Ilona Dahmen,Nadine Jahchan,Kwon-Sik Park,Dian Yang,Anthony N. Karnezis,Dedeepya Vaka,Ángela Torres,Maia Segura Wang,Jan O. Korbel,Roopika Menon,Sung-Min Chun,Deokhoon Kim,Matthew D. Wilkerson,Neil Hayes,David Engelmann,Brigitte M. Pützer,Marc Bos,Sebastian Michels,Ignacija Vlasic,Danila Seidel,Berit Pinther,Philipp Schaub,Christian Becker,Janine Altmüller,Jun Yokota,Takashi Kohno,Reika Iwakawa,Koji Tsuta,Masayuki Noguchi,Thomas Muley,Hans Hoffmann,Philipp A. Schnabel,Iver Petersen,Yuan Chen,Alex Soltermann,Verena Tischler,Chang-Min Choi,Yong-Hee Kim,Pierre P. Massion,Yong Zou,Dragana Jovanovic,Milica Kontic,Gavin M. Wright,Prudence A. Russell,Benjamin Solomon,Ina Koch,Michael Lindner,Lucia Anna Muscarella,Annamaria la Torre,John K. Field,Marko Jakopović,Jelena Knezevic,Esmeralda Castaños-Vélez,Luca Roz,Ugo Pastorino,O.T. Brustugun,Marius Lund-Iversen,Erik Thunnissen,Jens Köhler,Martin Schuler,Johan Botling,Martin Sandelin,Montserrat Sanchez-Cespedes,Helga B. Salvesen,Viktor Achter,Ulrich Lang,Magdalena Bogus,Peter M. Schneider,Thomas Zander,Sascha Ansén,Michael Hallek,Jürgen Wolf,Martin Vingron,Yasushi Yatabe,William D. Travis,Peter Nürnberg,Christian Reinhardt,Sven Perner,Lukas C. Heukamp,Reinhard Büttner,Stefan A. Haas,Elisabeth Brambilla,Martin Peifer,Julien Sage,Roman K. Thomas +95 more
TL;DR: This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.
Journal ArticleDOI
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Martin Peifer,Lynnette Fernandez-Cuesta,Martin L. Sos,Julie George,Danila Seidel,Lawryn H. Kasper,Dennis Plenker,Frauke Leenders,Ruping Sun,Thomas Zander,Roopika Menon,Mirjam Koker,Ilona Dahmen,Christian Müller,Vincenzo Di Cerbo,Hans Ulrich Schildhaus,Janine Altmüller,Ingelore Baessmann,Christian Becker,Bram De Wilde,Jo Vandesompele,Diana Böhm,Sascha Ansén,Franziska Gabler,Ines Wilkening,Stefanie Heynck,Johannes M. Heuckmann,Xin Lu,Scott L. Carter,Kristian Cibulskis,Shantanu Banerji,Gad Getz,Kwon-Sik Park,Daniel Rauh,Christian Grütter,Matthias Fischer,Laura Pasqualucci,Gavin M. Wright,Zoe Wainer,Prudence A. Russell,Iver Petersen,Yuan Chen,Erich Stoelben,Corinna Ludwig,Philipp A. Schnabel,Hans Hoffmann,Thomas Muley,Michael Brockmann,Walburga Engel-Riedel,Lucia Anna Muscarella,Vito Michele Fazio,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egber Smit,Daniëlle A M Heideman,Peter J.F. Snijders,Federico Cappuzzo,C. Ligorio,Stefania Damiani,John K. Field,Steinar Solberg,Odd Terje Brustugun,Marius Lund-Iversen,Jörg Sänger,Joachim H. Clement,Alex Soltermann,Holger Moch,Walter Weder,Benjamin Solomon,Jean-Charles Soria,Pierre Validire,Benjamin Besse,Elisabeth Brambilla,Christian Brambilla,Sylvie Lantuejoul,Philippe Lorimier,Peter M. Schneider,Michael Hallek,William Pao,Matthew Meyerson,Matthew Meyerson,Julien Sage,Jay Shendure,Robert Schneider,Robert Schneider,Reinhard Büttner,Jürgen Wolf,Peter Nürnberg,Sven Perner,Lukas C. Heukamp,Paul K. Brindle,Stefan A. Haas,Roman K. Thomas +94 more
TL;DR: This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.
Journal ArticleDOI
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.
Guido Rindi,David S. Klimstra,Behnoush Abedi-Ardekani,Sylvia L. Asa,Frederik T. Bosman,Elisabeth Brambilla,Klaus J. Busam,Ronald R. de Krijger,Manfred Dietel,Adel K. El-Naggar,Lynnette Fernandez-Cuesta,Günter Klöppel,W. Glenn McCluggage,Holger Moch,Hiroko Ohgaki,Emad A. Rakha,Nicholas S. Reed,Brian Rous,Hironobu Sasano,Aldo Scarpa,Jean-Yves Scoazec,William D. Travis,Giovanni Tallini,Jacqueline Trouillas,J. Han van Krieken,Ian A. Cree +25 more
TL;DR: This work believes this conceptual approach can form the basis for the next generation of NEN classifications and will allow more consistent taxonomy to understand how neoplasms from different organ systems inter-relate clinically and genetically.
Journal ArticleDOI
A genomics-based classification of human lung tumors
Danila Seidel,Thomas Zander,Lukas C. Heukamp,Martin Peifer,Marc Bos,Lynnette Fernandez-Cuesta,Frauke Leenders,Xin Lu,Sascha Ansén,Masyar Gardizi,Chau Nguyen,Chau Nguyen,Johannes Berg,Prudence A. Russell,Zoe Wainer,Hans-Ulrich Schildhaus,Hans-Ulrich Schildhaus,Toni-Maree Rogers,Benjamin Solomon,William Pao,Scott L. Carter,Gad Getz,D. Neil Hayes,Matthew D. Wilkerson,Erik Thunnissen,William D. Travis,Sven Perner,Gavin M. Wright,Elisabeth Brambilla,Reinhard Buettner,Juergen Wolf,Roman K. Thomas,Franziska Gabler,Ines Wilkening,Christian Mueller,Ilona Dahmen,Roopika Menon,Katharina Koenig,Kerstin Albus,Sabine Merkelbach-Bruse,Jana Fassunke,Katja Schmitz,Helen Kuenstlinger,Michaela Angelika Kleine,Elke Binot,Silvia Querings,Janine Altmueller,Ingelore Boessmann,Peter Nuemberg,Peter M. Schneider,Magdalena Bogus,Alex Soltermann,Holger Moch,Odd Terje Brustugun,Steinar Solberg,Marius Lund-Iversen,Åslaug Helland,Thomas Muley,Hans Hoffmann,Philipp A. Schnabel,Yuan Chen,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Joachim H. Clement,Walter Weder,Joerg Saenger,Erich Stoelben,Corinna Ludwig,Walburga Engel-Riedel,Egbert F. Smit,Danille A. M. Heideman,Peter J.F. Snijders,Lucia Nogova,Martin L. Sos,Christian Mattonet,Karin Toepelt,Matthias Scheffler,Eray Goekkurt,Eray Goekkurt,Rainer Kappes,Stefan Krueger,Kato Kambartel,Dirk Behringer,Wolfgang Schulte,Wolfgang Galetke,Winfried Randerath,Matthias Heldwein,Andreas Schlesinger,Monika Serke,Khosro Hekmat,Konrad Frank,Roland Schnell,Marcel Reiser,Ali-Nuri Huenerlituerkoglu,Stephan Schmitz,Lisa Meffert,Yon-Dschun Ko,Markus Litt-Lampe,Ulrich Gerigk,Rainer Fricke,Benjamin Besse,Christian Brambilla,Sylvie Lantuejoul,Philippe Lorimier,Denis Moro-Sibilot,Federico Cappuzzo,C. Ligorio,Stefania Damiani,John K. Field,Russell Hyde,Pierre Validire,Philippe Girard,Lucia Anna Muscarella,Vito Michele Fazio,Michael Hallek,Jean-Charles Soria,Viktor Achter,Ulrich Lang +118 more
TL;DR: Support is provided for broad implementation of genome-based diagnosis of lung cancer by demonstrating the correlation between lung tumor subtype and its predominant mutations, and the benefit of genetic testing and targeted therapy in these patients.
Journal ArticleDOI
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
Kadoaki Ohashi,Lecia V. Sequist,Maria E. Arcila,Teresa Moran,Juliann Chmielecki,Ya Lun Lin,Yumei Pan,Lu Wang,Elisa de Stanchina,Kazuhiko Shien,Keisuke Aoe,Shinichi Toyooka,Katsuyuki Kiura,Lynnette Fernandez-Cuesta,Panos Fidias,James Chih-Hsin Yang,Vincent A. Miller,Gregory J. Riely,Mark G. Kris,Jeffrey A. Engelman,Cindy L. Vnencak-Jones,Dora Dias-Santagata,Marc Ladanyi,William Pao +23 more
TL;DR: The data highlight the notion that, even though solid tumors share common signaling cascades, mediators of acquired resistance must be elucidated for each disease separately in the context of treatment.