T
Tamara L. Hendrickson
Researcher at Wayne State University
Publications - 56
Citations - 2134
Tamara L. Hendrickson is an academic researcher from Wayne State University. The author has contributed to research in topics: Transfer RNA & Genetic code. The author has an hindex of 21, co-authored 55 publications receiving 1874 citations. Previous affiliations of Tamara L. Hendrickson include California Institute of Technology & Johns Hopkins University.
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Journal ArticleDOI
Enzyme structure with two catalytic sites for double-sieve selection of substrate.
Osamu Nureki,Dmitry G. Vassylyev,Masaru Tateno,Atsushi Shimada,T. Nakama,Shuya Fukai,Mitiko Konno,Tamara L. Hendrickson,Paul Schimmel,Shigeyuki Yokoyama +9 more
TL;DR: The present crystal structures of the synthetase in complexes with L-isoleucine and L-valine demonstrate that the first sieve is on the aminoacylation domain containing the Rossmann fold, whereas the second, editing sieve exists on a globular beta-barrel domain that protrudes from the aminoACYlation domain.
Journal ArticleDOI
Incorporation of Nonnatural Amino Acids Into Proteins
TL;DR: The genetic code is established by the aminoacylation of transfer RNA, reactions in which each amino acid is linked to its cognate tRNA that, in turn, harbors the nucleotide triplet specific to the amino acid.
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Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.
Volker Döring,Henning D. Mootz,Leslie A. Nangle,Tamara L. Hendrickson,Valérie de Crécy-Lagard,Paul Schimmel,Philippe Marlière +6 more
TL;DR: The editing function may have played a central role in restricting the genetic code to 20 amino acids and disabling this editing function offers a powerful approach for diversifying the chemical composition of proteins and for emulating evolutionary stages of ambiguous translation.
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Computed structures of core eukaryotic protein complexes.
Ian R. Humphreys,Jimin Pei,Minkyung Baek,Aditya Krishnakumar,Ivan Anishchenko,Sergey Ovchinnikov,Jing Zhang,Travis J. Ness,Sudeep Banjade,Saket R. Bagde,Viktoriya G. Stancheva,Xiao-Han Li,Kaixian Liu,Zhi Zheng,Zhi Zheng,Daniel J. Barrero,Upasana Roy,Jochen Kuper,Israel S. Fernández,Barnabas Szakal,Dana Branzei,Josep Rizo,Caroline Kisker,Eric C. Greene,Sue Biggins,Scott Keeney,Scott Keeney,Elizabeth A. Miller,J. Christopher Fromme,Tamara L. Hendrickson,Qian Cong,David Baker +31 more
TL;DR: The structures of many eukaryotic protein complexes are unknown, and there are likely many protein-protein interactions not yet identified as mentioned in this paper, but these structures play critical roles in biology.