Tao Li

TL;DR: It is found that default mode network functional connectivity remains a prime target for understanding the pathophysiology of depression, with particular relevance to revealing mechanisms of effective treatments, and reduced rather than increased FC within the DMN is found.

TL;DR: The REST-meta-MDD Project of resting-state fMRI (R-fMRI) as mentioned in this paper investigated the functional connectivity (FC) within the default mode network (DMN), frequently reported to show increased FC in Major Depressive Disorder (MDD).

TL;DR: Wang et al. as mentioned in this paper found decreased default mode network functional connectivity in depressed patients, driven by patients with recurrent depression, and associated with current medication treatment but not with disease duration.

TL;DR: The pooled R-fMRI metrics of the REST-meta-MDD Project provide an unprecedented opportunity to investigate the key neural underpinnings of MDD and call for longitudinal brain imaging studies to understand the effects of medications, illness duration and severity.