Yan-Song Liu

TL;DR: It is found that default mode network functional connectivity remains a prime target for understanding the pathophysiology of depression, with particular relevance to revealing mechanisms of effective treatments, and reduced rather than increased FC within the DMN is found.

TL;DR: The findings suggest that excessive temporal variations of brain FC, reflecting abnormal communications between large-scale bran networks over time, may underlie the neuropathology of MDD.

TL;DR: Two subtypes with distinct default mode network profiles exist in major depression and Hyper- & hypo-connectivity DMN subgroups have comparable clinical symptom variables, according to validated datasets.

TL;DR: In this paper, a voxel-based whole-brain quantitative measure that reflects inter-and intra-hemispheric asymmetry was reported, which highlighted the idea that many brain networks contribute to broad clinical pathophysiology of MDD, and indicate that a lateralized, efficient and economical brain information processing system is disrupted in MDD.

TL;DR: In this article, the changes in regional gray matter volume (GMV) and gray matter density (GMD) in brain structure were found to correlate with the severity of major depressive disorder (MDD).