Tao Wang

TL;DR: The results suggest that 5-hmC-mediated epigenetic regulation may broadly impact the development of the human brain, and its dysregulation could contribute to the molecular pathogenesis of neurodevelopmental disorders.

TL;DR: It is shown that elevated expression of developmental regulators in G1 is a major determinant of heterogeneity in human embryonic stem cells, and cell-cycle regulation of developmentally regulated transcription factors is therefore an inherent feature of the mechanisms underpinning differentiation.

TL;DR: New evidence suggests that loss of FMRP causes presynaptic dysfunction and abnormal adult neurogenesis, and studies on FXS stem cells especially induced pluripotent stem (iPS) cells and new sequencing efforts hold out promise for deeper understanding of the silencing process and mutation spectrum of F MRP.

TL;DR: The excision of the expanded CGG-repeat from the fragile X chromosome can result in FMR1 reactivation and a decline in DNA methylation at the FMR 1 locus is demonstrated.

TL;DR: It is shown that 5hmC levels increase significantly during reprogramming to human iPSCs mainly owing to TET1 activation, and this hydroxymethylation change is critical for optimal epigenetic reprograming, but does not compromise primed pluripotency.