Tarek Z. Deeb

TL;DR: Blocking dephosphorylation of Ser940 reduced the glutamate-induced downregulation of KCC2 and substantially improved the maintenance of hyperpolarizing GABAergic inhibition.

TL;DR: Targeting KCC2 phosphorylation directly or indirectly via upstream regulatory kinases might be a novel strategy to modulate GABA- and/or glycinergic signaling for therapeutic benefit.

TL;DR: The report of two non‐synonymous functional variants in human KCC2, R952H and R1049C, exhibiting clear statistical association with idiopathic generalized epilepsy (IGE) are described and suggest genetically encoded impairment of K CC2 functional regulation may be a risk factor for the development of human IGE.

TL;DR: A combination of in-vivo quantitative proteomics and analyses of cyclin E knockout mice are used to demonstrate that in terminally differentiated neuronscyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk4 activity.

TL;DR: The growing evidence that KCC2 dysfunction has a central role in the development and severity of the epilepsies is discussed.