Bo Liang

TL;DR: The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral ribonucleoprotein as template, a non-canonical sequence of capping and methylation reactions, and polyadenylation of viral messages.

TL;DR: Targeting KCC2 phosphorylation directly or indirectly via upstream regulatory kinases might be a novel strategy to modulate GABA- and/or glycinergic signaling for therapeutic benefit.

TL;DR: A crystal structure of a specific complex of three archaeal H/ACA proteins, Cbf5, Nop10, and Gar1 is described and a dyskeratosis congenita mutation cluster site is identified within a modeled dyskerin structure.

TL;DR: The report of two non‐synonymous functional variants in human KCC2, R952H and R1049C, exhibiting clear statistical association with idiopathic generalized epilepsy (IGE) are described and suggest genetically encoded impairment of K CC2 functional regulation may be a risk factor for the development of human IGE.

TL;DR: The structural map of L provides new insights into the interrelationship of its various domains, and their rearrangement on P binding that is likely important for RNA synthesis.