T
Tatiana Akimova
Researcher at Children's Hospital of Philadelphia
Publications - 45
Citations - 4106
Tatiana Akimova is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: FOXP3 & T cell. The author has an hindex of 27, co-authored 43 publications receiving 3203 citations. Previous affiliations of Tatiana Akimova include University of Pennsylvania.
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Journal ArticleDOI
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Alessia Angelin,Luis Gil-de-Gómez,Satinder Dahiya,Jing Jiao,Lili Guo,Matthew H. Levine,Zhonglin Wang,William J. Quinn,Piotr K. Kopinski,Piotr K. Kopinski,Liqing Wang,Tatiana Akimova,Yujie Liu,Tricia R. Bhatti,Rongxiang Han,Benjamin L. Laskin,Joseph A. Baur,Ian A. Blair,Douglas C. Wallace,Douglas C. Wallace,Wayne W. Hancock,Ulf H. Beier +21 more
TL;DR: It is reported that the Treg transcription factor Foxp3 reprograms T cell metabolism by suppressing Myc and glycolysis, enhancing oxidative phosphorylation, and increasing nicotinamide adenine dinucleotide oxidation, which allows Tregs a metabolic advantage in low-glucose, lactate-rich environments.
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Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.
Evgeniy Eruslanov,Pratik Bhojnagarwala,Jon G. Quatromoni,Tom L. Stephen,Anjana Ranganathan,Charuhas Deshpande,Tatiana Akimova,Anil Vachani,Leslie A. Litzky,Wayne W. Hancock,Jose R. Conejo-Garcia,Michael Feldman,Steven M. Albelda,Sunil Singhal +13 more
TL;DR: It is demonstrated that in the earliest stages of lung cancer, TANs are not immunosuppressive, but rather stimulate T cell responses.
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Helios Expression Is a Marker of T Cell Activation and Proliferation
TL;DR: Investigation of Helios expression in murine and human T cells under resting or activating conditions, using well-characterized molecules of naïve/effector/memory phenotypes, as well as a set of Treg-associated markers found that Helios-negative T cells are enriched for naïve T cell phenotypes and vice versa.
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Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.
Edwin F. de Zoeten,Liqing Wang,Kyle V. Butler,Ulf H. Beier,Tatiana Akimova,Hong Sai,James E. Bradner,Ralph Mazitschek,Alan P. Kozikowski,Patrick Matthias,Wayne W. Hancock +10 more
TL;DR: It is shown that HDAC6 inhibition promotes Treg suppressive activity in models of inflammation and autoimmunity, including multiple forms of experimental colitis and fully major histocompatibility complex (MHC)-incompatible cardiac allograft rejection.
Journal ArticleDOI
Substrate Rigidity Regulates Human T Cell Activation and Proliferation
Roddy S. O’Connor,Xueli Hao,Keyue Shen,Keenan T. Bashour,Tatiana Akimova,Wayne W. Hancock,Lance C. Kam,Michael C. Milone +7 more
TL;DR: The results reveal that the rigidity of the substrate used to immobilize T cell stimulatory ligands is an important and previously unrecognized parameter influencing T cell activation, proliferation, and Th differentiation.