T
Tatsuya Kikuchi
Researcher at National Institute of Radiological Sciences
Publications - 46
Citations - 649
Tatsuya Kikuchi is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: Acetylcholinesterase & Methylpurine. The author has an hindex of 13, co-authored 43 publications receiving 453 citations.
Papers
More filters
Journal ArticleDOI
High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
Kenji Tagai,Kenji Tagai,Maiko Ono,Manabu Kubota,Manabu Kubota,Soichiro Kitamura,Soichiro Kitamura,Keisuke Takahata,Keisuke Takahata,Chie Seki,Yuhei Takado,Hitoshi Shinotoh,Yasunori Sano,Yasunori Sano,Yasuharu Yamamoto,Yasuharu Yamamoto,Kiwamu Matsuoka,Kiwamu Matsuoka,Hiroyuki Takuwa,Masafumi Shimojo,Manami Takahashi,Kazunori Kawamura,Tatsuya Kikuchi,Maki Okada,Haruhiko Akiyama,Hisaomi Suzuki,Hisaomi Suzuki,Mitsumoto Onaya,Takahiro Takeda,Kimihito Arai,Nobutaka Arai,Nobuyuki Araki,Yuko Saito,John Q. Trojanowski,Virginia M.-Y. Lee,Sushil Kumar Mishra,Yoshiki Yamaguchi,Yasuyuki Kimura,Masanori Ichise,Yutaka Tomita,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Masahiro Shigeta,Naruhiko Sahara,Makoto Higuchi,Hitoshi Shimada +46 more
TL;DR: The in vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pick's disease, PSP, and corticobasal degeneration patients who underwent PET scans.
Posted ContentDOI
High-contrast in-vivo imaging of tau pathologies in Alzheimer’s and non-Alzheimer’s disease tauopathies
Kenji Tagai,Kenji Tagai,Maiko Ono,Manabu Kubota,Manabu Kubota,Soichiro Kitamura,Soichiro Kitamura,Keisuke Takahata,Keisuke Takahata,Chie Seki,Yuhei Takado,Hitoshi Shinotoh,Yasunori Sano,Yasunori Sano,Kiwamu Matsuoka,Kiwamu Matsuoka,Hiroyuki Takuwa,Masafumi Shimojo,Manami Takahashi,Kazunori Kawamura,Tatsuya Kikuchi,Maki Okada,Haruhiko Akiyama,Hisaomi Suzuki,Hisaomi Suzuki,Mitsumoto Onaya,Takahiro Takeda,Kimihito Arai,Nobutaka Arai,Nobuyuki Araki,Yuko Saito,Yasuyuki Kimura,Masanori Ichise,Yutaka Tomita,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Masahiro Shigeta,Naruhiko Sahara,Makoto Higuchi,Hitoshi Shimada +40 more
TL;DR: The in-vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of autopsied and biopsied brains derived from Pick′s disease, PSP and corticobasal degeneration patients who underwent PET scans.
Journal ArticleDOI
Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain.
Toshimitsu Okamura,Tatsuya Kikuchi,Maki Okada,Chie Toramatsu,Kiyoshi Fukushi,Makoto Takei,Toshiaki Irie +6 more
TL;DR: An in vivo method is described, which overcomes limitations for assessing MRP1 function, using positron emission tomography (PET) and a PET probe, and allows noninvasive and quantitative assessment for MRp1 function in the living brain.
Journal ArticleDOI
Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography.
Tsuneyoshi Ota,Hitoshi Shinotoh,Kiyoshi Fukushi,Tatsuya Kikuchi,Koichi Sato,Noriko Tanaka,Hitoshi Shimada,Shigeki Hirano,Michie Miyoshi,Heii Arai,Tetsuya Suhara,Toshiaki Irie +11 more
TL;DR: The plasma IC50 value was estimated from plasma donepezil concentrations and cerebral cortical mean AChE inhibition rates measured by positron emission tomography, using one-parameter model, and it was found that higher dose ofdonepezil might provide further benefits for patients with AD.
Journal ArticleDOI
Therapeutic Efficacy of C-Kit-Targeted Radioimmunotherapy Using 90Y-Labeled Anti-C-Kit Antibodies in a Mouse Model of Small Cell Lung Cancer
Chisato Yoshida,Atsushi B. Tsuji,Hitomi Sudo,Aya Sugyo,Tatsuya Kikuchi,Mitsuru Koizumi,Yasushi Arano,Tsuneo Saga +7 more
TL;DR: Treatment with [ 90Y]12A8 and [90Y]67A2 achieved a complete therapeutic response when SY tumors received an absorbed dose greater than 18 Gy and thus are promising RIT agents for metastatic SCLC cells at distant sites.