M
Manami Takahashi
Researcher at National Institute of Radiological Sciences
Publications - 19
Citations - 370
Manami Takahashi is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: Tauopathy & Biology. The author has an hindex of 5, co-authored 14 publications receiving 112 citations.
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Journal ArticleDOI
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Yuji Nagai,Naohisa Miyakawa,Hiroyuki Takuwa,Yukiko Hori,Kei Oyama,Bin Ji,Manami Takahashi,Xi Ping Huang,Samuel T. Slocum,Jeffrey F. DiBerto,Yan Xiong,Takuya Urushihata,Toshiyuki Hirabayashi,Atsushi Fujimoto,Koki Mimura,Justin G. English,Jing Liu,Ken-ichi Inoue,Ken-ichi Inoue,Katsushi Kumata,Chie Seki,Maiko Ono,Masafumi Shimojo,Ming-Rong Zhang,Yutaka Tomita,Jin Nakahara,Tetsuya Suhara,Masahiko Takada,Makoto Higuchi,Jian Jin,Bryan L. Roth,Takafumi Minamimoto +31 more
TL;DR: DCZ represents a potent, selective, metabolically stable and fast-acting DREADD agonist with utility in both mice and nonhuman primates for a variety of applications.
Journal ArticleDOI
High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
Kenji Tagai,Kenji Tagai,Maiko Ono,Manabu Kubota,Manabu Kubota,Soichiro Kitamura,Soichiro Kitamura,Keisuke Takahata,Keisuke Takahata,Chie Seki,Yuhei Takado,Hitoshi Shinotoh,Yasunori Sano,Yasunori Sano,Yasuharu Yamamoto,Yasuharu Yamamoto,Kiwamu Matsuoka,Kiwamu Matsuoka,Hiroyuki Takuwa,Masafumi Shimojo,Manami Takahashi,Kazunori Kawamura,Tatsuya Kikuchi,Maki Okada,Haruhiko Akiyama,Hisaomi Suzuki,Hisaomi Suzuki,Mitsumoto Onaya,Takahiro Takeda,Kimihito Arai,Nobutaka Arai,Nobuyuki Araki,Yuko Saito,John Q. Trojanowski,Virginia M.-Y. Lee,Sushil Kumar Mishra,Yoshiki Yamaguchi,Yasuyuki Kimura,Masanori Ichise,Yutaka Tomita,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Masahiro Shigeta,Naruhiko Sahara,Makoto Higuchi,Hitoshi Shimada +46 more
TL;DR: The in vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pick's disease, PSP, and corticobasal degeneration patients who underwent PET scans.
Posted ContentDOI
High-contrast in-vivo imaging of tau pathologies in Alzheimer’s and non-Alzheimer’s disease tauopathies
Kenji Tagai,Kenji Tagai,Maiko Ono,Manabu Kubota,Manabu Kubota,Soichiro Kitamura,Soichiro Kitamura,Keisuke Takahata,Keisuke Takahata,Chie Seki,Yuhei Takado,Hitoshi Shinotoh,Yasunori Sano,Yasunori Sano,Kiwamu Matsuoka,Kiwamu Matsuoka,Hiroyuki Takuwa,Masafumi Shimojo,Manami Takahashi,Kazunori Kawamura,Tatsuya Kikuchi,Maki Okada,Haruhiko Akiyama,Hisaomi Suzuki,Hisaomi Suzuki,Mitsumoto Onaya,Takahiro Takeda,Kimihito Arai,Nobutaka Arai,Nobuyuki Araki,Yuko Saito,Yasuyuki Kimura,Masanori Ichise,Yutaka Tomita,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Masahiro Shigeta,Naruhiko Sahara,Makoto Higuchi,Hitoshi Shimada +40 more
TL;DR: The in-vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of autopsied and biopsied brains derived from Pick′s disease, PSP and corticobasal degeneration patients who underwent PET scans.
Posted ContentDOI
In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05
Maiko Ono,Manami Takahashi,Aki Shimozawa,Masayuki Fujinaga,Wakana Mori,Yuji Nagai,Koki Mimura,Katsushi Kumata,Tatsuya Kikuchi,Masafumi Shimojo,Hiroyuki Takuwa,Takeharu Minamihisamatsu,Shoko Uchida,Sushil K. Mishra,Yoshiki Yamaguchi,Hiroshi Shimizu,Akiyoshi Kakita,Hironobu Endo,Yuhei Takado,Takafumi Minamimoto,Naruhiko Sahara,Ming-Rong Zhang,Masato Hasegawa,Makoto Higuchi +23 more
TL;DR: A new imaging technology enabling etiological and therapeutic assessments of α-synuclein pathogenesis at non-clinical levels is proposed, highlighting the applicability of C05-05 to clinical PET.
Journal ArticleDOI
Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow
Takuya Urushihata,Takuya Urushihata,Hiroyuki Takuwa,Chie Seki,Yasuhiko Tachibana,Manami Takahashi,Jeff Kershaw,Yuhei Takado,Ichio Aoki,Makoto Higuchi,Hiroshi Ito,Takayuki Obata +11 more
TL;DR: The results suggest the injury of neuronal fibers due to chronic hypoperfusion and it is suggested that CBF-related signal changes should be considered when DWI-based information is used for pathological diagnosis.