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Yasuharu Yamamoto
Researcher at Keio University
Publications - 19
Citations - 199
Yasuharu Yamamoto is an academic researcher from Keio University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 9 publications receiving 51 citations. Previous affiliations of Yasuharu Yamamoto include National Institute of Radiological Sciences.
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Journal ArticleDOI
High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
Kenji Tagai,Kenji Tagai,Maiko Ono,Manabu Kubota,Manabu Kubota,Soichiro Kitamura,Soichiro Kitamura,Keisuke Takahata,Keisuke Takahata,Chie Seki,Yuhei Takado,Hitoshi Shinotoh,Yasunori Sano,Yasunori Sano,Yasuharu Yamamoto,Yasuharu Yamamoto,Kiwamu Matsuoka,Kiwamu Matsuoka,Hiroyuki Takuwa,Masafumi Shimojo,Manami Takahashi,Kazunori Kawamura,Tatsuya Kikuchi,Maki Okada,Haruhiko Akiyama,Hisaomi Suzuki,Hisaomi Suzuki,Mitsumoto Onaya,Takahiro Takeda,Kimihito Arai,Nobutaka Arai,Nobuyuki Araki,Yuko Saito,John Q. Trojanowski,Virginia M.-Y. Lee,Sushil Kumar Mishra,Yoshiki Yamaguchi,Yasuyuki Kimura,Masanori Ichise,Yutaka Tomita,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Masahiro Shigeta,Naruhiko Sahara,Makoto Higuchi,Hitoshi Shimada +46 more
TL;DR: The in vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pick's disease, PSP, and corticobasal degeneration patients who underwent PET scans.
Journal ArticleDOI
Evaluation of [18F]PI-2620, a second-generation selective tau tracer, for assessing four-repeat tauopathies.
Toshiki Tezuka,Keisuke Takahata,Keisuke Takahata,Morinobu Seki,Hajime Tabuchi,Yuki Momota,Mika Shiraiwa,Natsumi Suzuki,Ayaka Morimoto,Tadaki Nakahara,Yu Iwabuchi,Eisuke Miura,Yasuharu Yamamoto,Yasunori Sano,Kei Funaki,Bun Yamagata,Ryo Ueda,Takahito Yoshizaki,Kyoko Mashima,Mamoru Shibata,Mamoru Shibata,Munenori Oyama,Kensuke Okada,Masahito Kubota,Hajime Okita,Masaki Takao,Masahiro Jinzaki,Jin Nakahara,Masaru Mimura,Daisuke Ito +29 more
TL;DR: In this paper, a tau PET tracer, [18F]PI-2620, has a high binding affinity and specificity for aggregated tau; therefore, it was hypothesized to have desirable properties for the visualization of tau accumulation in Alzheimer's disease and non-Alzheimer's disease tauopathies.
Journal ArticleDOI
Machine-learning approach to predict on-road driving ability in healthy older people.
Yasuharu Yamamoto,Jinichi Hirano,Hiroshi Yoshitake,Kazuno Negishi,Masaru Mimura,Motoki Shino,Bun Yamagata +6 more
TL;DR: A new sensing method is identified for the evaluation of the on‐road driving ability of healthy older people on the basis of vehicle behaviors to detect older drivers who are cognitively normal but at high risk of having fatal traffic accidents.
Journal ArticleDOI
Differential associations of dopamine synthesis capacity with the dopamine transporter and D2 receptor availability as assessed by PET in the living human brain.
Yasuharu Yamamoto,Keisuke Takahata,Manabu Kubota,Harumasa Takano,Hiroyoshi Takeuchi,Yasuyuki Kimura,Yasunori Sano,Shin Kurose,Hiroshi Ito,Masaru Mimura,Makoto Higuchi +10 more
TL;DR: The intimate association of the DA synthesis rate with the presynaptic reuptake of DA indicates homeostatic maintenance of the baseline synaptic DA concentration.
Journal ArticleDOI
Regional Gray Matter Volume Identifies High Risk of Unsafe Driving in Healthy Older People.
Yasuharu Yamamoto,Bun Yamagata,Jinichi Hirano,Ryo Ueda,Hiroshi Yoshitake,Kazuno Negishi,Mika Yamagishi,Mariko Kimura,Kei Kamiya,Motoki Shino,Masaru Mimura +10 more
TL;DR: Findings indicate that the cortical regions implicated in voluntary orienting of attention, decision making, and working memory may constitute the essential neural basis of driving behavior.