Y
Yuhei Takado
Researcher at National Institute of Radiological Sciences
Publications - 28
Citations - 429
Yuhei Takado is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: Tauopathy & Glutamate receptor. The author has an hindex of 8, co-authored 27 publications receiving 180 citations.
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Journal ArticleDOI
High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
Kenji Tagai,Kenji Tagai,Maiko Ono,Manabu Kubota,Manabu Kubota,Soichiro Kitamura,Soichiro Kitamura,Keisuke Takahata,Keisuke Takahata,Chie Seki,Yuhei Takado,Hitoshi Shinotoh,Yasunori Sano,Yasunori Sano,Yasuharu Yamamoto,Yasuharu Yamamoto,Kiwamu Matsuoka,Kiwamu Matsuoka,Hiroyuki Takuwa,Masafumi Shimojo,Manami Takahashi,Kazunori Kawamura,Tatsuya Kikuchi,Maki Okada,Haruhiko Akiyama,Hisaomi Suzuki,Hisaomi Suzuki,Mitsumoto Onaya,Takahiro Takeda,Kimihito Arai,Nobutaka Arai,Nobuyuki Araki,Yuko Saito,John Q. Trojanowski,Virginia M.-Y. Lee,Sushil Kumar Mishra,Yoshiki Yamaguchi,Yasuyuki Kimura,Masanori Ichise,Yutaka Tomita,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Masahiro Shigeta,Naruhiko Sahara,Makoto Higuchi,Hitoshi Shimada +46 more
TL;DR: The in vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pick's disease, PSP, and corticobasal degeneration patients who underwent PET scans.
Posted ContentDOI
High-contrast in-vivo imaging of tau pathologies in Alzheimer’s and non-Alzheimer’s disease tauopathies
Kenji Tagai,Kenji Tagai,Maiko Ono,Manabu Kubota,Manabu Kubota,Soichiro Kitamura,Soichiro Kitamura,Keisuke Takahata,Keisuke Takahata,Chie Seki,Yuhei Takado,Hitoshi Shinotoh,Yasunori Sano,Yasunori Sano,Kiwamu Matsuoka,Kiwamu Matsuoka,Hiroyuki Takuwa,Masafumi Shimojo,Manami Takahashi,Kazunori Kawamura,Tatsuya Kikuchi,Maki Okada,Haruhiko Akiyama,Hisaomi Suzuki,Hisaomi Suzuki,Mitsumoto Onaya,Takahiro Takeda,Kimihito Arai,Nobutaka Arai,Nobuyuki Araki,Yuko Saito,Yasuyuki Kimura,Masanori Ichise,Yutaka Tomita,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Masahiro Shigeta,Naruhiko Sahara,Makoto Higuchi,Hitoshi Shimada +40 more
TL;DR: The in-vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of autopsied and biopsied brains derived from Pick′s disease, PSP and corticobasal degeneration patients who underwent PET scans.
Journal ArticleDOI
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
Masafumi Shimojo,Hiroyuki Takuwa,Yuhei Takado,Masaki Tokunaga,Satoshi Tsukamoto,Keiichiro Minatohara,Maiko Ono,Chie Seki,Jun Maeda,Takuya Urushihata,Takeharu Minamihisamatsu,Ichio Aoki,Kazunori Kawamura,Ming-Rong Zhang,Tetsuya Suhara,Naruhiko Sahara,Makoto Higuchi +16 more
TL;DR: The findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegnerative tauopathies.
Journal ArticleDOI
First prototyping of a dedicated PET system with the hemisphere detector arrangement.
Hideaki Tashima,Eiji Yoshida,Yuma Iwao,Hidekatsu Wakizaka,Takamasa Maeda,Chie Seki,Yasuyuki Kimura,Yuhei Takado,Makoto Higuchi,Tetsuya Suhara,Taichi Yamashita,Taiga Yamaya +11 more
TL;DR: Novel geometries of a hemisphere detector arrangement for high-sensitivity brain imaging, in which an add-on detector at the chin position or neck position helps in sensitivity uniformity improvement are proposed, showed to have high potential for realizing high-Sensitivity, high-resolution, and low-cost brain PET imaging.
Journal ArticleDOI
Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer’s disease
Soichiro Kitamura,Hitoshi Shimada,Fumitoshi Niwa,Hironobu Endo,Hitoshi Shinotoh,Keisuke Takahata,Manabu Kubota,Yuhei Takado,Shigeki Hirano,Yasuyuki Kimura,Ming-Rong Zhang,Satoshi Kuwabara,Tetsuya Suhara,Makoto Higuchi +13 more
TL;DR: The present findings suggested that tau pathology in OFC may provoke focal neurotoxicity inOFC and the following disruption of the OFC-UNC network, leading to the emergence and progression of apathy in AD.