T
Terence J. Campbell
Researcher at Victor Chang Cardiac Research Institute
Publications - 98
Citations - 4494
Terence J. Campbell is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: hERG & Disopyramide. The author has an hindex of 37, co-authored 98 publications receiving 4335 citations. Previous affiliations of Terence J. Campbell include University of Oxford & St. Vincent's Health System.
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Journal ArticleDOI
Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification.
TL;DR: Using the parameters of speed of onset of rate-dependent depression of Vmax and APD it was possible to subdivide the nine Class I anti-arrhythmic drugs into three distinct subclasses.
Journal ArticleDOI
HERG K+ channels: friend and foe
TL;DR: The K+ channel encoded by the human ether-à-go-go related gene (HERG) is one of many ion channels that are crucial for normal action potential repolarization in cardiac myocytes.
Journal ArticleDOI
Off‐label use of medicines: consensus recommendations for evaluating appropriateness
Madlen Gazarian,Maria Kelly,John McPhee,Linda V Graudins,Robyn L. Ward,Robyn L. Ward,Terence J. Campbell,Terence J. Campbell +7 more
TL;DR: The development of a guide for clinicians, policymakers and funders of health care in evaluating the appropriateness of medicines proposed for off‐label use is described and three broad categories of appropriate off-label use are identified.
Journal ArticleDOI
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
Stephen J. Harrop,Matthew Z. DeMaere,W.D. Fairlie,T. Reztsova,Stella M. Valenzuela,Michele Mazzanti,Raffaella Tonini,Min Ru Qiu,Lucy Jankova,Kristina Warton,Asne R. Bauskin,W.M. Wu,S. Pankhurst,Terence J. Campbell,Samuel N. Breit,Paul M. G. Curmi +15 more
TL;DR: The structure indicates that CLIC1 is likely to be controlled by redox-dependent processes.
Journal ArticleDOI
The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.
Dene R. Littler,Stephen J. Harrop,W. Douglas Fairlie,Louise J. Brown,Greg J. Pankhurst,S. Pankhurst,Matthew Z. DeMaere,Terence J. Campbell,Asne R. Bauskin,Raffaella Tonini,Michele Mazzanti,Samuel N. Breit,Paul M. G. Curmi +12 more
TL;DR: The crystal structure of this oxidized CLIC1 dimer is determined and it is shown that a major structural transition has occurred, exposing a large hydrophobic surface, which forms the dimer interface.