Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
Stephen J. Harrop,Matthew Z. DeMaere,W.D. Fairlie,T. Reztsova,Stella M. Valenzuela,Michele Mazzanti,Raffaella Tonini,Min Ru Qiu,Lucy Jankova,Kristina Warton,Asne R. Bauskin,W.M. Wu,S. Pankhurst,Terence J. Campbell,Samuel N. Breit,Paul M. G. Curmi +15 more
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The structure indicates that CLIC1 is likely to be controlled by redox-dependent processes.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-11-30 and is currently open access. It has received 209 citations till now. The article focuses on the topics: Transmembrane domain & Ion channel.read more
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Quantitative reactivity profiling predicts functional cysteines in proteomes
Eranthie Weerapana,Chu Wang,Gabriel M. Simon,Florian Richter,Sagar D. Khare,Myles B. D. Dillon,Daniel A. Bachovchin,Kerri A. Mowen,David Baker,Benjamin F. Cravatt +9 more
TL;DR: It is demonstrated that quantitative reactivity profiling can form the basis for screening and functional assignment of cysteines in computationally designed proteins, where it discriminated catalytically active from inactive cysteine hydrolase designs.
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The changing faces of glutathione, a cellular protagonist
TL;DR: The significance of GSH as a major factor in regulation of cell life, proliferation, and death, should be regarded as the integrated result of all these roles it can play.
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Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system.
TL;DR: Glutaredoxins uniquely reduce mixed disulfides with glutathione via a monothiol mechanism where only an N-terminal low pKa Cys residue is required, by using their glutathionylation site.
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A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
TL;DR: The role of sulfur interactions in protein structure and function is discussed and although relatively rare, intermolecular interactions between ligand C-S σ* orbitals and proteins are illustrated.
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Glutathione transferases in the genomics era : New insights and perspectives
TL;DR: This review focuses on glutathione transferases (GSTs), an ancient protein superfamily with multiple roles in all eukaryotic organisms, and attempts to give an overview of the new insights and perspectives provided by omics into the biology of these proteins.
References
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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Stephen F. Altschul,Thomas L. Madden,Alejandro A. Schäffer,Jinghui Zhang,Zheng Zhang,Webb Miller,David J. Lipman +6 more
TL;DR: A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original.
Book ChapterDOI
Processing of X-ray diffraction data collected in oscillation mode
Zbyszek Otwinowski,Wladek Minor +1 more
TL;DR: The methods presented in the chapter have been applied to solve a large variety of problems, from inorganic molecules with 5 A unit cell to rotavirus of 700 A diameters crystallized in 700 × 1000 × 1400 A cell.
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PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Journal ArticleDOI
The CCP4 suite: programs for protein crystallography
TL;DR: The CCP4 (Collaborative Computational Project, number 4) program suite is a collection of programs and associated data and subroutine libraries which can be used for macromolecular structure determination by X-ray crystallography.
Journal ArticleDOI
Refinement of macromolecular structures by the maximum-likelihood method.
TL;DR: The likelihood function for macromolecular structures is extended to include prior phase information and experimental standard uncertainties and the results derived are consistently better than those obtained from least-squares refinement.