T
Terry B. Strom
Researcher at Beth Israel Deaconess Medical Center
Publications - 373
Citations - 27700
Terry B. Strom is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Transplantation & T cell. The author has an hindex of 82, co-authored 373 publications receiving 26714 citations. Previous affiliations of Terry B. Strom include University of Cologne.
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Journal ArticleDOI
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
Journal ArticleDOI
IL-21 initiates an alternative pathway to induce proinflammatory T H 17 cells
Thomas Korn,Estelle Bettelli,Wenda Gao,Amit Awasthi,Anneli Jäger,Terry B. Strom,Mohamed Oukka,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6-deficient (Il6-/-) mice do not develop a TH17 response and their peripheral repertoire is dominated by Foxp3+ Treg cells, suggesting an additional pathway by which TH17 cells might be generated in vivo.
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Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Dan H. Barouch,Sampa Santra,Jörn E. Schmitz,Marcelo J. Kuroda,Tong-Ming Fu,Wendeline Wagner,Miroslawa Bilska,Abie Craiu,Xin Xiao Zheng,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Christine E. Nickerson,Wendy L. Trigona,Kara Punt,Dan C. Freed,Liming Guan,Sheri Dubey,Danilo R. Casimiro,Adam J. Simon,Mary-Ellen Davies,Michael Chastain,Terry B. Strom,Rebecca Gelman,David C. Montefiori,Mark G. Lewis,Emilio A. Emini,John W. Shiver,Norman L. Letvin +28 more
TL;DR: The protective efficacy of vaccine-elicited immune responses against a pathogenic SHIV-89.6P challenge in rhesus monkeys is reported, with no evidence of clinical disease or mortality after challenge.
Journal ArticleDOI
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
TL;DR: The data indicate that induction of T-cell apoptosis and peripheral allograft tolerance is prevented by blocking both signal 1 and signal 2 ofT-cell activation.
Journal ArticleDOI
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Li-Fan Lu,Evan F. Lind,David C. Gondek,Kathy A. Bennett,Michael W Gleeson,Karina Pino-Lagos,Zachary A. Scott,Anthony J. Coyle,Jennifer L. Reed,Jacques Van Snick,Terry B. Strom,Xin Xiao Zheng,Randolph J. Noelle +12 more
TL;DR: The results obtained in this study establish that mast cells are essential in CD4+CD25+Foxp3+ regulatory T (TReg)-cell-dependent peripheral tolerance, and indicate that IL-9 represents the functional link through which activated TReg cells recruit and activate mast cells to mediate regional immune suppression.