T
Teruyuki Muraguchi
Researcher at Kanazawa University
Publications - 8
Citations - 1100
Teruyuki Muraguchi is an academic researcher from Kanazawa University. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 8, co-authored 8 publications receiving 1011 citations.
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Journal ArticleDOI
TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
Kazuhito Naka,Takayuki Hoshii,Teruyuki Muraguchi,Yuko Tadokoro,Takako Ooshio,Yukio Kondo,Shinji Nakao,Noboru Motoyama,Atsushi Hirao +8 more
TL;DR: A critical role for the TGF-β–FOXO pathway in the maintenance of LICs is demonstrated, and the understanding of the mechanisms that specifically maintain CML LICs in vivo is strengthened.
Journal ArticleDOI
Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells
TL;DR: Repression of intracellular ROS levels in HSCs by treatment with an antioxidant that scavenges ROS can rescue HSC functions, indicating that excess ROS levels are at the root of HSC failure.
Journal ArticleDOI
mTORC1 is essential for leukemia propagation but not stem cell self-renewal
Takayuki Hoshii,Yuko Tadokoro,Kazuhito Naka,Takako Ooshio,Teruyuki Muraguchi,Naoyuki Sugiyama,Tomoyoshi Soga,Kimi Araki,Ken Ichi Yamamura,Atsushi Hirao +9 more
TL;DR: Transplantation of Raptor-deficient undifferentiated AML cells in a limiting dilution revealed that mTORC1 is essential for leukemia initiation, and it was demonstrated that the reactivation of m TORC1 in those cells restored their leukemia-initiating capacity.
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Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin
Akira Tamase,Teruyuki Muraguchi,Kazuhito Naka,Shingo Tanaka,Masashi Kinoshita,Takayuki Hoshii,Masako Ohmura,Haruhiko Shugo,Takako Ooshio,Mitsutoshi Nakada,Kazunobu Sawamoto,Masafumi Onodera,Kunio Matsumoto,Masanobu Oshima,Masahide Asano,Hideyuki Saya,Hideyuki Okano,Toshio Suda,Jun-ichiro Hamada,Atsushi Hirao +19 more
TL;DR: The clonal studies conclusively established that phenotypical heterogeneity can exist among the cells comprising a genetically homogeneous tumor, suggesting that this aggressive brain tumor follows the CSC model.
Journal ArticleDOI
Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.
Takeshi Motohara,Sachiko Masuko,Takatsugu Ishimoto,Toshifumi Yae,Nobuyuki Onishi,Teruyuki Muraguchi,Atsushi Hirao,Yumi Matsuzaki,Hironori Tashiro,Hidetaka Katabuchi,Hideyuki Saya,Osamu Nagano +11 more
TL;DR: A role for p53 in the development and expansion of ovarian stem-like tumor cells and subsequent malignant progression is revealed.