T
Tetsuya Higuchi
Researcher at Toho University
Publications - 27
Citations - 1210
Tetsuya Higuchi is an academic researcher from Toho University. The author has contributed to research in topics: CD40 & T cell. The author has an hindex of 12, co-authored 27 publications receiving 1142 citations. Previous affiliations of Tetsuya Higuchi include University of Münster & Tokyo Medical and Dental University.
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Journal ArticleDOI
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
Akira Suzuki,Manae Tsukio Yamaguchi,Toshiaki Ohteki,Takehiko Sasaki,Tsuneyasu Kaisho,Yuki Kimura,Ritsuko Yoshida,Andrew Wakeham,Tetsuya Higuchi,Manabu Fukumoto,Takeshi Tsubata,Pamela S. Ohashi,Shigeo Koyasu,Josef M. Penninger,Toru Nakano,Tak W. Mak +15 more
TL;DR: PTEN, a tumor suppressor gene, is essential for embryogenesis and an important regulator of T cell homeostasis and self-tolerance in Pten(flox/-) mice.
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Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease
Tetsuya Higuchi,Yuichi Aiba,Takashi Nomura,Junichiro Matsuda,Keiji Mochida,Misao Suzuki,Hitoshi Kikutani,Tasuku Honjo,Kiyoshi Nishioka,Takeshi Tsubata +9 more
TL;DR: It is indicated that CD40L on B cells causes lupus-like disease in the presence of yet unknown environmental factors that by themselves do not induce the disease.
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Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation
Georg Varga,Sandra Balkow,Martin K. Wild,Martin K. Wild,Andrea Stadtbaeumer,Mathias Krummen,Tobias Rothoeft,Tetsuya Higuchi,Stefan Beissert,Klaus Wethmar,Klaus Wethmar,Karin Scharffetter-Kochanek,Dietmar Vestweber,Dietmar Vestweber,Stephan Grabbe +14 more
TL;DR: It is concluded that active CD11b/CD18 (Mac-1) on APCs directly inhibits T-cell activation and the antigen-presenting capacity of macrophages, which express constitutively active beta2 integrins, is significantly enhanced on Mac-1 blockade.
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An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice.
Karin Loser,Andrea Scherer,Mathias Krummen,Georg Varga,Tetsuya Higuchi,Thomas Schwarz,Thomas Schwarz,Arlene H. Sharpe,Stephan Grabbe,Jeffrey A. Bluestone,Stefan Beissert +10 more
TL;DR: Data indicate that blocking CD80/86-CTLA-4 signaling induced immune protection against the development of UV-induced skin tumors and that CD86-mediated costimulation appears to play a more critical role in the protection against photocarcinogenesis than CD80.
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Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice
Tsutomu Yoshida,Tetsuya Higuchi,Hiroyuki Hagiyama,Andreas Strasser,Kiyoshi Nishioka,Takeshi Tsubata +5 more
TL;DR: It is demonstrated that expression of either CrmA, the cowpox virus serpin, or an inhibitor of the adapter protein FADD/MORT1 blocks Fas-mediated apoptosis but has no effect on BCR ligation-induced apoptosis of the B cell line WEHI-231, and that BCR-mediated suicides does not require Fas or related molecules such as DR3, DR4 and DR5.