T
Thad A. Harroun
Researcher at Brock University
Publications - 100
Citations - 5496
Thad A. Harroun is an academic researcher from Brock University. The author has contributed to research in topics: Membrane & Lipid bilayer. The author has an hindex of 34, co-authored 97 publications receiving 5064 citations. Previous affiliations of Thad A. Harroun include Chalk River Laboratories & Indiana University – Purdue University Indianapolis.
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Barrel-Stave Model or Toroidal Model? A Case Study on Melittin Pores
TL;DR: It is concluded that, among naturally produced peptides that are investigated, only alamethicin conforms to the barrel-stave model, and other peptides, including magainins, melittin and protegrins, all appear to induce transmembrane pores that conform to the toroidal model.
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Membrane Pores Induced by Magainin
TL;DR: In this paper, a toroidal wormhole model was proposed to detect helical magainin 2 in the skin of Xenopus laevis, where a substantial fraction of the peptide is oriented perpendicular to the membrane.
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Experimental Evidence for Hydrophobic Matching and Membrane- Mediated Interactions in Lipid Bilayers Containing Gramicidin
TL;DR: These experiments confirm the conjecture that when proteins are embedded in a membrane, hydrophobic matching creates a strain field in the lipid bilayer that in turn gives rise to a membrane-mediated attractive potential between proteins.
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Cholesterol shows preference for the interior of polyunsaturated lipid membranes.
TL;DR: The simulations allow us to analyze the behavior of cholesterol in detail and show that the interaction of cholesterol with the PUFA chains of DAPC leads to a fast flip-flop rate for the sterol and an increased preference ofThe sterol for the unusual location embedded between the monolayer leaflets.
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The location and behavior of α‐tocopherol in membranes
TL;DR: This work hypothesizes that alpha-tocopherol partitions into domains that are enriched in polyunsaturated phospholipids, amplifying the concentration of the vitamin in the place where it is most needed, and experimental evidence in support of the formation of PUFA-rich domains in model membranes is presented.