Theodore N. Mellin

TL;DR: Mc3r and Mc4r serve non-redundant roles in the regulation of energy homeostasis by studying Mc3r-deficient mice and comparing their functions in mice deficient for both genes.

TL;DR: It is shown that the previously described orphan G-protein-coupled receptor FM-3 and a newly discovered one (FM-4) are cognate receptors for NMU, which provides a molecular basis for the biochemical activities of NMU and may indicate that NMU is involved in the central control of feeding.

TL;DR: It is concluded that MC-4R can mediate control of both metabolic rate and food intake in mice, and it is inferred that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic Rate andFood intake in wildtype mice seems limited.

TL;DR: Excisional dermal wound healing is impaired in mice with a targeted deletion in the stromelysin-1 gene and these data implicateStromelys in-1 proteolysis during early wound contraction and indicate that stromeolysis is crucial for the organization of a multicellular actin network.

TL;DR: Injured rat carotid arteries were treated by i.v. administration of acidic fibroblast growth factor, a heparin-binding protein that is chemotactic and mitogenic for vascular endothelial cells and resulted in dose-dependent inhibition of intimal thickening with parallel promotion of endothelial regeneration over the injured area.