Myrna E. Trumbauer

TL;DR: Mice deficient in inducible nitric oxide synthase (iNOS) were generated to test the idea that iNOS defends the host against infectious agents and tumor cells at the risk of contributing to tissue damage and shock, and found there exist both iN OS-dependent and iNos-independent routes to LPS-induced hypotension and death.

TL;DR: A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the structural gene of rat growth hormone was microinjected into the pronuclei of fertilized mouse eggs, and seven mice developed that carried the fusion gene and six of these grew significantly larger than their littermates.

TL;DR: The overall efficiency of microinjection of foreign DNA into fertilized mammalian eggs depends on the choice of mouse strains; for example, generating transgenic mice that express foreign growth hormone genes is about eight times easier with C57/BL6 X SJL hybrid mice than with inbred C57-BL6 mice.

TL;DR: Mc3r and Mc4r serve non-redundant roles in the regulation of energy homeostasis by studying Mc3r-deficient mice and comparing their functions in mice deficient for both genes.

TL;DR: Mice generated with targeted disruptions of PS1 alleles exhibited abnormal patterning of the axial skeleton and spinal ganglia, phenotypes traced to defects in somite segmentation and differentiation, suggesting PS1 is required for the spatiotemporal expression of Notch 1 and Dll 1, which are essential for somite segmentsation and maintenance of somite borders.