D
Donna L. Hreniuk
Researcher at Merck & Co.
Publications - 31
Citations - 5895
Donna L. Hreniuk is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Thyrotropin-releasing hormone receptor. The author has an hindex of 23, co-authored 31 publications receiving 5675 citations.
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Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.
Journal ArticleDOI
Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
Maria A. Bednarek,Scott D. Feighner,Sheng-Shung Pong,Karen K. McKee,Donna L. Hreniuk,M V Silva,Vivien A. Warren,Andrew D. Howard,L. H. T. Van Der Ploeg,J V Heck +9 more
TL;DR: The entire sequence of ghrelin is not necessary for activity: the Gly-Ser-Ser(n-octanoyl)-Phe segment appears to constitute the "active core" required for agonist potency at hGHSR1a.
Journal ArticleDOI
Receptor for motilin identified in the human gastrointestinal system.
Scott D. Feighner,Carina P. Tan,Karen K. McKee,Oksana C. Palyha,Donna L. Hreniuk,Sheng-Shung Pong,Christopher P. Austin,David J. Figueroa,Douglas J. MacNeil,Margaret A. Cascieri,Ravi P. Nargund,Raman K. Bakshi,Mark Abramovitz,Rino Stocco,Stacia Kargman,Gary P. O'Neill,Lex H. T. Van Der,Ploeg,Jilly F. Evans,Arthur A. Patchett,Roy G. Smith,Andrew D. Howard +21 more
TL;DR: Development of motilin receptor agonists and antagonists may be useful in the treatment of multiple disorders of GI motility.
Journal ArticleDOI
Identification of receptors for neuromedin U and its role in feeding
Andrew D. Howard,Ruiping Wang,Sheng-Shung Pong,Theodore N. Mellin,Alison M. Strack,Xiao-Ming Guan,Zhizhen Zeng,David L. Williams,Scott D. Feighner,Christian N. Nunes,Beth Ann Murphy,Judith N. Stair,Hong Yu,Qingping Jiang,Michelle K. Clements,Carina P. Tan,Karen K. McKee,Donna L. Hreniuk,Terrence P. McDonald,Kevin R. Lynch,Jilly F. Evans,Christopher P. Austin,C. Thomas Caskey,Lex H.T. Van der Ploeg,Qingyun Liu +24 more
TL;DR: It is shown that the previously described orphan G-protein-coupled receptor FM-3 and a newly discovered one (FM-4) are cognate receptors for NMU, which provides a molecular basis for the biochemical activities of NMU and may indicate that NMU is involved in the central control of feeding.
Journal ArticleDOI
Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors
Karen K. McKee,Oksana C. Palyha,Scott D. Feighner,Donna L. Hreniuk,Carina P. Tan,Michael S. Phillips,Roy G. Smith,Lex H.T. Van der Ploeg,Andrew D. Howard +8 more
TL;DR: The recent cloning of the GHS-R from human and swine pituitary gland identifies yet a third G protein-coupled receptor (GPC-R) involved in the control of GH release and further supports the existence of an undiscovered hormone that may activate this receptor.