Thies Schroeder

TL;DR: In this paper, the authors identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism.

TL;DR: Elevated tumor lactate concentrations are associated with the subsequent development of nodal or distant metastases in head-and-neck cancer patients and this more aggressive malignant phenotype is probably associated with hypoxia-mediated radioresistance and the upregulation of metastasis-associated genes.

TL;DR: It is revealed that HIF-1 plays an important role in determining tumor radioresponsiveness through regulating four distinct processes, including promoting ATP metabolism, proliferation, and p53 activation, which has a radiosensitizing effect on tumors.

TL;DR: It is proposed that determination of lactate in primary tumors may serve as a basis for a novel metabolic classification which can lead to an improvement of prognosis and therapy in clinical oncology.

TL;DR: Genome-scale gene expression studies are developed to dissect transcriptional responses of primary human mammary epithelial cells to lactic acidosis and hypoxia in vitro and to explore how they are linked to clinical tumor phenotypes in vivo, and the utility of genomic analysis that maps expression-based findings from in vitro experiments to human samples is demonstrated.