Stefan Walenta

TL;DR: It is shown that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells, and is a potent inhibitor of function and survival of T andNK cells leading to tumor immune escape.

TL;DR: It is concluded that tumor lactate content may be used as a prognostic parameter in the clinic and in accordance with data from the literature showing that the presence of hypoxia in cervical tumors is associated with a poorer patient survival.

TL;DR: Elevated tumor lactate concentrations are associated with the subsequent development of nodal or distant metastases in head-and-neck cancer patients and this more aggressive malignant phenotype is probably associated with hypoxia-mediated radioresistance and the upregulation of metastasis-associated genes.

TL;DR: The hypercatabolic nature of TIS that is therapeutically exploitable by synthetic lethal metabolic targeting is unveiled, which is a consequence of the senescence-associated secretory phenotype (SASP) described previously.

TL;DR: It is proposed that determination of lactate in primary tumors may serve as a basis of a novel metabolic classification, which can lead to an improvement of prognosis and therapy in clinical oncology.