T
Thomas Arzberger
Researcher at Ludwig Maximilian University of Munich
Publications - 184
Citations - 16710
Thomas Arzberger is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Progressive supranuclear palsy & Neurodegeneration. The author has an hindex of 59, co-authored 171 publications receiving 13409 citations. Previous affiliations of Thomas Arzberger include German Center for Neurodegenerative Diseases & University of Würzburg.
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Journal ArticleDOI
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry.
TL;DR: To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis.
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Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
Günter U. Höglinger,Gesine Respondek,Maria Stamelou,Carolin Kurz,Keith A. Josephs,Anthony E. Lang,Brit Mollenhauer,Ulrich Müller,Christer Nilsson,Jennifer L. Whitwell,Thomas Arzberger,Elisabet Englund,Ellen Gelpi,Armin Giese,David J. Irwin,Wassilios G. Meissner,Wassilios G. Meissner,Alexander Pantelyat,Alex Rajput,John C. van Swieten,Claire Troakes,Angelo Antonini,Kailash P. Bhatia,Yvette Bordelon,Yaroslau Compta,Jean-Christophe Corvol,Carlo Colosimo,Dennis W. Dickson,Richard Dodel,Leslie W. Ferguson,Murray Grossman,Jan Kassubek,Florian Krismer,Johannes Levin,Stefan Lorenzl,Huw R. Morris,Peter J. Nestor,Wolfgang H. Oertel,Werner Poewe,Gil D. Rabinovici,James B. Rowe,Gerard D. Schellenberg,Klaus Seppi,Thilo van Eimeren,Gregor K. Wenning,Adam L. Boxer,Lawrence I. Golbe,Irene Litvan +47 more
TL;DR: Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome.
Journal ArticleDOI
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
Kohji Mori,Shih-Ming Weng,Thomas Arzberger,Stephanie May,Kristin Rentzsch,Elisabeth Kremmer,Bettina Schmid,Bettina Schmid,Hans A. Kretzschmar,Marc Cruts,Christine Van Broeckhoven,Christian Haass,Christian Haass,Dieter Edbauer,Dieter Edbauer +14 more
TL;DR: It is found that characteristic intracellular inclusions of misfolded proteins define C9orf72 pathology, but the core proteins of the majority of inclusions are still unknown, and a new class of proteins links a common genetic mutation to the predominant pathology in certain neurodegenerative diseases.
Journal ArticleDOI
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
Kohji Mori,Thomas Arzberger,Thomas Arzberger,Friedrich A. Grässer,Ilse Gijselinck,Stephanie May,Kristin Rentzsch,Shih Ming Weng,Martin H. Schludi,Julie van der Zee,Marc Cruts,Christine Van Broeckhoven,Elisabeth Kremmer,Hans A. Kretzschmar,Christian Haass,Christian Haass,Dieter Edbauer,Dieter Edbauer +17 more
TL;DR: The data show that the GGGGCC repeat is bidirectionally translated into five distinct DPR proteins that co-aggregate in the characteristic p62-positive TDP-43 negative inclusions found in FTLD/ALS cases with C9orf72 repeat expansion.
Journal ArticleDOI
Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium
Irina Alafuzoff,Thomas Arzberger,Safa Al-Sarraj,Istvan Bodi,Nenad Bogdanovic,Heiko Braak,Orso Bugiani,Kelly Del-Tredici,Isidro Ferrer,Ellen Gelpi,Giorgio Giaccone,Manuel B. Graeber,Paul G. Ince,Wouter Kamphorst,Andrew T. King,Penelope Korkolopoulou,Gabor G. Kovacs,Sergey Larionov,David Meyronet,Camelia M. Monoranu,Piero Parchi,Efstratios Patsouris,Wolfgang Roggendorf,Danielle Seilhean,Fabrizio Tagliavini,Christine Stadelmann,Nathalie Streichenberger,Dietmar Rudolf Thal,Dietmar Rudolf Thal,Stephen B. Wharton,Hans A. Kretzschmar +30 more
TL;DR: The results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures, whereas when only mild subtle lesions were present the agreement was poorer, and it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.