Jan Kassubek

TL;DR: Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome.

TL;DR: In a multinational, double-blind, placebo-controlled trial (NCT00474058), 287 subjects with Parkinson's disease (PD) and unsatisfactory early-morning motor symptom control were randomized 2:1 to receive rotigotine (2-16 mg/24 hr [n = 190] or placebo (n = 97) as discussed by the authors.

TL;DR: The topography of cerebral volume changes associated with Huntington’s disease can be mapped using VBM and it can be shown that cerebral grey matter changes co-vary with clinical severity and CAG repeat length.

TL;DR: The results suggest that the lipid metabolism and the nutritional status of ALS patients are important prognostic factors and should be thoroughly monitored during the clinical management of these patients, and that lipid-lowering drugs, e.g., statins, should be applied carefully in ALS patients although individual risk considerations must be made.

TL;DR: Neurofilaments in CSF have a high relevance for the differential diagnosis of MNDs and should be included in the diagnostic work-up of patients and their value as prognostic markers should be investigated further.