T
Thomas Binz
Researcher at Hochschule Hannover
Publications - 109
Citations - 11203
Thomas Binz is an academic researcher from Hochschule Hannover. The author has contributed to research in topics: Synaptobrevin & Synaptic vesicle. The author has an hindex of 50, co-authored 107 publications receiving 10718 citations. Previous affiliations of Thomas Binz include University of Giessen & University of California, Irvine.
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Journal ArticleDOI
A Cell Line for Detection of Botulinum Neurotoxin Type B.
Aleksander Rust,Ciara Doran,Rosalyn Hart,Thomas Binz,Paul Stickings,Dorothea Sesardic,Andrew A. Peden,Bazbek Davletov +7 more
TL;DR: A novel SiMa cell-based approach where re-engineering of the VAMP molecule allows detection of all BoNT/B intoxication steps using a luminescent enzymatic reaction with sensitivity comparable to mouse LD50 bioassay is described.
Journal ArticleDOI
Characterization of the Borna disease virus phosphoprotein, p23.
S Kliche,Lothar Stitz,Harry Mangalam,Licheng Shi,Thomas Binz,H Niemann,Thomas Briese,W I Lipkin +7 more
TL;DR: Cross-reactivity with monospecific sera and monoclonal antibodies to p40 was found for one discontinuous epitope located at the amino terminus of p23, and eight continuous epitopes accessible on the surface of a predicted structural model for the monomeric and the disulfide-linked dimeric forms of p24.
Botulinum and Tetanus Neurotoxins
Heiner Niemann,Thomas Binz,Oliver Grebenstein,Hisao Kurazono,A. Kalkuhl,S. Yamasaki,Ulrich L. M. Eisel,Johannes Pohlner,Germar Schneider,Viliam Krivan,Shunji Kozaki,S. Mochida,Ladislav Tauc,Bernard Poulain +13 more
TL;DR: Chlorpromazine increased the phosphorylated state of a number of phosphoproteins with apparent molecular weights (MrS) between 40 and 60 kilodaltons and was inhibited in a concentration and temperature-dependent manner.
Journal ArticleDOI
Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells
TL;DR: It is shown that following retinoic acid treatment, human neuroblastoma cells, SiMa and SH-SY5Y, acquire a neuronal phenotype evidenced by axonal growth and expression of neuronal markers.
Journal ArticleDOI
Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells.
Jason Arsenault,Sabine A. G. Cuijpers,Enrico Ferrari,Enrico Ferrari,Dhevahi Niranjan,Aleksander Rust,Charlotte Leese,John A. O'Brien,Thomas Binz,Bazbek Davletov,Bazbek Davletov +10 more
TL;DR: It is shown for the first time that previously observed cytotoxicity of botulinum neurotoxins/C in neurons could be achieved in cells of neuroendocrine origin with implications for medical uses ofBotulinum preparations.