T
Thomas Binz
Researcher at Hochschule Hannover
Publications - 109
Citations - 11203
Thomas Binz is an academic researcher from Hochschule Hannover. The author has contributed to research in topics: Synaptobrevin & Synaptic vesicle. The author has an hindex of 50, co-authored 107 publications receiving 10718 citations. Previous affiliations of Thomas Binz include University of Giessen & University of California, Irvine.
Papers
More filters
Journal ArticleDOI
Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity.
TL;DR: A dual role is assigned to SNAP-25 and it is suggested that its nine C-terminal amino acids are directly involved in coupling the calcium sensor to the final step in exocytosis.
Journal ArticleDOI
Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis
E. Link,Lisa Edelmann,Judy H. Chou,Thomas Binz,S. Yamasaki,Ulrich L. M. Eisel,M Baumert,Thomas C. Südhof,Heiner Niemann,Reinhard Jahn,Reinhard Jahn +10 more
TL;DR: It is demonstrated that blockade of neurotransmission by tetanus toxin in isolated nerve terminals is associated with a selective proteolysis of synaptobrevin, an integral membrane protein of synaptic vesicles, and data suggest that cleavage ofsynaptob revin is the molecular mechanism of tetanus toxins action.
Journal ArticleDOI
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
TL;DR: A peptide comprising the intravesicular domain between transmembrane domains 7 and 8 specifically reduces the neurotoxicity of BoNT/A at phrenic nerve preparations demonstrating the physiological relevance of this interaction.
Journal ArticleDOI
The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins.
TL;DR: The complete sequence of botulinum neurotoxin type A (BoNT/A; 1,296 amino acid residues, Mr = 149,425) and a partial sequence ofotoxin type E (273 amino acids residues) as deduced from the corresponding nucleotide sequences of the chromosomally located structural genes are established.
Journal ArticleDOI
Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
S. Yamasaki,A. Baumeister,Thomas Binz,Juan Blasi,E. Link,Fabrice Cornille,Bernard P. Roques,E. M. Fykse,Thomas C. Südhof,Reinhard Jahn +9 more
TL;DR: It is shown that BoNT/D cleaves rat synaptobrevin 1 and 2 in toxified synaptosomes and in isolated vesicles and that the presence of Val76 instead of Gln76 dictates the reduced cleavability of synaptOBrevin isoforms by TeTx.