T
Thomas Clairfeuille
Researcher at University of Queensland
Publications - 17
Citations - 710
Thomas Clairfeuille is an academic researcher from University of Queensland. The author has contributed to research in topics: Sorting nexin & SNX27. The author has an hindex of 10, co-authored 16 publications receiving 515 citations. Previous affiliations of Thomas Clairfeuille include Spanish National Research Council & Genentech.
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Journal ArticleDOI
A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer
Matthew Gallon,Thomas Clairfeuille,Florian Steinberg,Caroline Mas,Rajesh Ghai,Richard B. Sessions,Rohan D. Teasdale,Brett M. Collins,Peter J. Cullen +8 more
TL;DR: This work provides the first step, to the authors' knowledge, in the molecular description of this important sorting complex, and more broadly describes a unique interaction between a PDZ domain and an arrestin-like fold.
Journal ArticleDOI
A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex
Thomas Clairfeuille,Caroline Mas,Audrey S. M. Chan,Zhe Yang,Maria Tello-Lafoz,Mintu Chandra,Jocelyn Widagdo,Markus C. Kerr,Blessy Paul,Isabel Mérida,Rohan D. Teasdale,Nathan J. Pavlos,Victor Anggono,Brett M. Collins +13 more
TL;DR: This work defines specific acidic amino acid sequences upstream of the PDZ-binding motif required for high-affinity engagement of the human SNX27 PDZ domain and identifies conserved sites of phosphorylation that substitute for acidic residues and dramatically enhanceSNX27 interactions.
Journal ArticleDOI
Structural basis of α-scorpion toxin action on Nav channels
Thomas Clairfeuille,Alexander Cloake,Alexander Cloake,Daniel T. Infield,José P. Llongueras,Christopher P. Arthur,Zhong Rong Li,Yuwen Jian,Marie-France Martin-Eauclaire,Pierre E. Bougis,Claudio Ciferri,Christopher A. Ahern,Frank Bosmans,David H. Hackos,Alexis Rohou,Jian Payandeh +15 more
TL;DR: Structures reveal how activation of voltage-gated sodium channels causes conformational changes in a voltage-sensor domain, leading to fast inactivation, and pharmacological trapping of VSD4 reveals state-dependent interactions of gating charges from the S4 helix and S4-S5 linker.
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Structure of the essential inner membrane lipopolysaccharide-PbgA complex.
Thomas Clairfeuille,Kerry R Buchholz,Qingling Li,Erik Verschueren,Peter Liu,Dewakar Sangaraju,Summer Park,Cameron L. Noland,Kelly M. Storek,Nicholas N. Nickerson,L. Martin,Trisha Dela Vega,Anh Miu,Janina Reeder,Maria Ruiz-Gonzalez,Danielle L. Swem,Guanghui Han,Daniel P. DePonte,Mark S. Hunter,Cornelius Gati,Cornelius Gati,Sheerin K. Shahidi-Latham,Min Xu,Nicholas J. Skelton,Benjamin D. Sellers,Elizabeth Skippington,Wendy Sandoval,Emily J. Hanan,Jian Payandeh,Steven T. Rutherford +29 more
TL;DR: It is found that PbgA has an unexpected but essential role in the regulation of LPS biogenesis, presents a new structural basis for the selective recognition of lipids, and provides opportunities for future antibiotic discovery.
Journal ArticleDOI
Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth.
Audrey S. M. Chan,Thomas Clairfeuille,Euphemie Landao-Bassonga,Genevieve Kinna,Pei Ying Ng,Li Shen Loo,Tak Sum Cheng,Minghao Zheng,Wanjin Hong,Rohan D. Teasdale,Brett M. Collins,Nathan J. Pavlos +11 more
TL;DR: The endocytic protein SNX27 functions to link the parathyroid hormone receptor (PTHR) to the retromer trafficking complex and is a new modulator of PTHR signaling.