Thomas Desaive

TL;DR: If implemented, these recommendations have the potential to minimize the discrepancies in the conduct and reporting of clinical trials and to improve glucose control in clinical practice.

TL;DR: Continuous monitoring of the patient-specific Elung and Edrs and minimally invasive PEEP titration provide a unique, patient- specific and physiologically relevant metric to optimize PEEP selection with minimal disruption of MV therapy.

TL;DR: A review of TGC via new analyses of data from several clinical trials, including SPRINT, Glucontrol and a recent NICU study is provided, which provides both a review of the problem and major background factors driving it, as well as a novel model-based analysis designed to examine these dynamics from a new perspective.

TL;DR: In this paper, a review examines the models and methods used to create virtual patients and how these virtual patients can be used in silico to test different protocols or interventions, or in real-time to guide care.

TL;DR: SPRINT TGC resolved organ failure faster, and for more patients, from similar admission and maximum SOFA scores, than conventional control, and these reductions mirror the reduced mortality with SPRINT.