L
Laurent Loufrani
Researcher at University of Angers
Publications - 98
Citations - 4424
Laurent Loufrani is an academic researcher from University of Angers. The author has contributed to research in topics: Vasodilation & Mesenteric arteries. The author has an hindex of 38, co-authored 92 publications receiving 4016 citations. Previous affiliations of Laurent Loufrani include University of Nantes & French Institute of Health and Medical Research.
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Journal ArticleDOI
Polycystin-1 and -2 Dosage Regulates Pressure Sensing
Reza Sharif-Naeini,Joost H.A. Folgering,Delphine Bichet,Fabrice Duprat,Inger Lauritzen,Malika Arhatte,Martine Jodar,Alexandra Dedman,Franck C. Chatelain,Uwe Schulte,Kevin Retailleau,Laurent Loufrani,Amanda Patel,Frederick Sachs,Patrick Delmas,Dorien J.M. Peters,Eric Honoré +16 more
TL;DR: This work uncovers a role for polycystins in regulating pressure sensing and shows that TRPP2 interacts with filamin A and demonstrates that this actin crosslinking protein is critical for SAC regulation.
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The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure
Christophe Guilluy,Christophe Guilluy,Jérémy Brégeon,Jérémy Brégeon,Gilles Toumaniantz,Gilles Toumaniantz,Malvyne Rolli-Derkinderen,Malvyne Rolli-Derkinderen,Kevin Retailleau,Laurent Loufrani,Daniel Henrion,Elizabeth Scalbert,Antoine Bril,Raul M. Torres,Stephan Offermanns,Pierre Pacaud,Pierre Pacaud,Gervaise Loirand,Gervaise Loirand +18 more
TL;DR: Evidence is provided that Arhgef1 is the RhoA guanine exchange factor specifically responsible for angiotensin II–induced activation of RHoA signaling in arterial smooth muscle cells and identifies Arh gef1 as a potential target for the treatment of hypertension.
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Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease
Stéphane M. Camus,João Alfredo Moraes,Philippe Bonnin,Paul Abbyad,Sylvain Le Jeune,François Lionnet,Laurent Loufrani,Linda Grimaud,Jean-Christophe Lambry,Dominique Charue,Laurent Kiger,Jean-Marie Renard,Claire Larroque,Hervé Le Clésiau,Alain Tedgui,Patrick Bruneval,Christina Barja-Fidalgo,Antigoni Alexandrou,Pierre-Louis Tharaux,Chantal M. Boulanger,Olivier Blanc-Brude +20 more
TL;DR: In transgenic SAD mice, infusion of heme-laden MPs triggered rapid vasoocclusions in kidneys and compromised microvascular dilation ex vivo, and may provide new targets for the therapeutic preservation of vascular function in SCD.
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Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis
Ivo Buschmann,Axel R. Pries,Beata Styp-Rekowska,Philipp Hillmeister,Laurent Loufrani,Daniel Henrion,Yu Shi,André Duelsner,Imo E. Hoefer,Nora Gatzke,Haitao Wang,Kerstin Lehmann,Lena Ulm,Zully Ritter,Peter Hauff,Ruslan Hlushchuk,Valentin Djonov,Toon van Veen,Ferdinand le Noble +18 more
TL;DR: It is concluded that pulsatile shear patterns may be central for supporting arterial identity, and that arterial Gja5 expression plays a functional role in flow-driven arteriogenesis.
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The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure
Aurelie Nguyen Dinh Cat,Violaine Griol-Charhbili,Laurent Loufrani,Carlos Labat,Laura E. Benjamin,Nicolette Farman,Patrick Lacolley,Daniel Henrion,Frederic Jaisser +8 more
TL;DR: It is demonstrated that enhanced MR activation in the endothelium generates an increase in blood pressure, independent of stimulation of renal tubular Na+ transport by aldo/MR or direct activation of smooth muscle MR, and establish one mechanism by which endothelial MR activation per se may contribute to impaired vascular reactivity.