T
Thomas H. Clarke
Researcher at Washington and Lee University
Publications - 22
Citations - 918
Thomas H. Clarke is an academic researcher from Washington and Lee University. The author has contributed to research in topics: Spider silk & Spidroin. The author has an hindex of 11, co-authored 19 publications receiving 715 citations. Previous affiliations of Thomas H. Clarke include J. Craig Venter Institute & University of California, Riverside.
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Journal ArticleDOI
The house spider genome reveals an ancient whole-genome duplication during arachnid evolution
Evelyn E. Schwager,Evelyn E. Schwager,Prashant P. Sharma,Thomas H. Clarke,Thomas H. Clarke,Thomas H. Clarke,Daniel J. Leite,Torsten Wierschin,Matthias Pechmann,Yasuko Akiyama-Oda,Lauren A. Esposito,Jesper Bechsgaard,Trine Bilde,Alexandra D. Buffry,Hsu Chao,Huyen Dinh,Harshavardhan Doddapaneni,Shannon Dugan,Cornelius Eibner,Cassandra G. Extavour,Peter Funch,Jessica E. Garb,Luis Baudouin Gonzalez,Vanessa L. González,Sam Griffiths-Jones,Yi Han,Cheryl Y. Hayashi,Cheryl Y. Hayashi,Maarten Hilbrant,Maarten Hilbrant,Daniel S.T. Hughes,Ralf Janssen,Sandra L. Lee,Ignacio Maeso,Shwetha C. Murali,Donna M. Muzny,Rodrigo Nunes da Fonseca,Christian L. B. Paese,Jiaxin Qu,Matthew Ronshaugen,Christoph Schomburg,Anna Schoenauer,Angelika Stollewerk,Montserrat Torres-Oliva,Natascha Turetzek,Bram Vanthournout,Bram Vanthournout,John H. Werren,Carsten Wolff,Kim C. Worley,Gregor Bucher,Richard A. Gibbs,Jonathan A. Coddington,Hiroki Oda,Mario Stanke,Nadia A. Ayoub,Nikola-Michael Prpic,Jean-François Flot,Nico Posnien,Stephen Richards,Alistair P. McGregor +60 more
TL;DR: The results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA, and this study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes ofpolyploidization events across eukaryotes.
Journal ArticleDOI
Multi-tissue transcriptomics of the black widow spider reveals expansions, co-options, and functional processes of the silk gland gene toolkit
Thomas H. Clarke,Jessica E. Garb,Cheryl Y. Hayashi,Robert A. Haney,Alex K. Lancaster,Alex K. Lancaster,Susan Corbett,Nadia A. Ayoub +7 more
TL;DR: A transcriptional program for the silk glands is proposed that involves regulating gland specific synthesis of silk fiber and glue components followed by protecting and processing these components into functional fibers and glues.
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Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics
TL;DR: A black widow venom specific exome is presented that uncovers a trove of diverse toxins and associated proteins, suggesting a dynamic evolutionary history, and justifies a reevaluation of the functional activities ofblack widow venom in light of its emerging complexity.
Journal ArticleDOI
Spider Transcriptomes Identify Ancient Large-Scale Gene Duplication Event Potentially Important in Silk Gland Evolution.
TL;DR: An ancient large-scale gene duplication event within the spider lineage was likely an important source of molecular novelty during the evolution of silk gland-specific expression.
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Evidence from Multiple Species that Spider Silk Glue Component ASG2 is a Spidroin
TL;DR: It is shown that spidroins have diversified into glues in addition to task-specific, high performance fibers, indicating that ASG2 is a member of thespidroin gene family.