Shan Naidu

TL;DR: The Pten–Ets2 axis is identified as a critical stroma-specific signalling pathway that suppresses mammary epithelial tumours and ameliorated disruption of the tumour microenvironment.

TL;DR: There is significant functional redundancy among activators and that the specific requirement for E2f3a during postnatal development is dictated by regulatory sequences governing its selective spatiotemporal expression and not by its intrinsic protein functions, providing a molecular basis for the observed specificity among E2F activators during development.

TL;DR: The results show that STAT3 is necessary for ovarian tumor progression/metastasis and highlight the potential for targeting STAT3 by HO-3867 as a therapeutic strategy for ovarian cancer.

TL;DR: In this paper, the authors modeled three sentinel mutant alleles of PTEN identified in patients with Cowden syndrome and show that the nonsense Pten∆4-5 and missense PtenC124R and PtenG129E alleles lacking lipid phosphatase activity cause similar developmental abnormalities but distinct tumor spectra with varying severity and age of onset.

TL;DR: The development of a novel class of bifunctional STAT3 inhibitors, based on conjugation of a diarylidenyl-piperidone backbone to an N-hydroxypyrroline (-NOH) group, which exhibits minimal toxicity against normal cells and good oral bioavailability and offers preclinical proof-of-concept for HO-3867 as a selective STAT3 inhibitor to treat ovarian cancer and other solid tumors where STAT3 is widely upregulated.