T
Thomas Lorey
Researcher at Kaiser Permanente
Publications - 89
Citations - 3306
Thomas Lorey is an academic researcher from Kaiser Permanente. The author has contributed to research in topics: Cervical cancer & Cervical intraepithelial neoplasia. The author has an hindex of 30, co-authored 81 publications receiving 2626 citations. Previous affiliations of Thomas Lorey include University of California, Berkeley & Yeshiva University.
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Journal ArticleDOI
Reassurance Against Future Risk of Precancer and Cancer Conferred by a Negative Human Papillomavirus Test
Julia C. Gage,Mark Schiffman,Hormuzd A. Katki,Philip E. Castle,Barbara Fetterman,Nicolas Wentzensen,Nancy Poitras,Thomas Lorey,Li C. Cheung,Walter Kinney +9 more
TL;DR: Risks of cancer and cervical intraepithelial neoplasia grade 3 or worse for the three strategies among 1011092 women aged 30 to 64 years testing HPV-negative and/or Pap-negative in routine screening at Kaiser Permanente Northern California since 2003 are estimated and compared.
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HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis
Lisa Mirabello,Meredith Yeager,Kai Yu,Gary M. Clifford,Yanzi Xiao,Bin Zhu,Michael Cullen,Michael Cullen,Joseph Boland,Joseph Boland,Nicolas Wentzensen,Chase W. Nelson,Tina Raine-Bennett,Zigui Chen,Sara Bass,Sara Bass,Lei Song,Lei Song,Qi Yang,Qi Yang,Mia Steinberg,Mia Steinberg,Laurie Burdett,Laurie Burdett,Michael Dean,David Roberson,David Roberson,Jason Mitchell,Jason Mitchell,Thomas Lorey,Silvia Franceschi,Philip E. Castle,Joan L. Walker,Rosemary E. Zuna,Aimée R. Kreimer,Daniel C. Beachler,Allan Hildesheim,Paula Gonzalez,Carolina Porras,Robert D. Burk,Mark Schiffman +40 more
TL;DR: Strict conservation of the 98 amino acids of E7, which disrupts Rb function, is critical for HPV16 carcinogenesis, presenting a highly specific target for etiologic and therapeutic research.
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Benchmarking CIN 3+ risk as the basis for incorporating HPV and Pap cotesting into cervical screening and management guidelines.
Hormuzd A. Katki,Mark Schiffman,Philip E. Castle,Barbara Fetterman,Nancy Poitras,Thomas Lorey,Li C. Cheung,Tina Raine-Bennett,Julia C. Gage,Walter Kinney +9 more
TL;DR: Using the principle of “equal management of equal risks,” benchmarking to implicit risk thresholds based on Pap-alone can be used to achieve safe and consistent incorporation of cotesting.
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HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women.
Lisa Mirabello,Meredith Yeager,Michael Cullen,Joseph Boland,Zigui Chen,Nicolas Wentzensen,Xijun Zhang,Kai Yu,Qi Yang,Jason Mitchell,David Roberson,Sara Bass,Yanzi Xiao,Laurie Burdett,Tina Raine-Bennett,Thomas Lorey,Philip E. Castle,Robert D. Burk,Mark Schiffman +18 more
TL;DR: Specific HPV16 variant sublineages strongly influence risk of histologic types of precancer and cancer, and viral genetic variation may help explain its unique carcinogenic properties.
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Five-year experience of human papillomavirus DNA and papanicolaou test cotesting
TL;DR: Concerns about excessive HPV test positives among women aged 30 years and older are not borne out in a general screening population of women 30 and older using data from Kaiser Permanente Northern California.