Thomas Prebet

TL;DR: The results show that ASXL1 might play the role of a tumour suppressor in myeloid malignancies, a disease classified as MDS/Myeloproliferative disorder.

TL;DR: Outcome after AZA failure is poor, and allogeneic stem-cell transplantation and investigational agents were associated with a better outcome when compared with conventional clinical care.

TL;DR: It is shown that in a niche-like coculture system, cells from both primary and cultured acute myeloid leukemia (AML) sources take up functional mitochondria from murine or human bone marrow stromal cells, and mitochondrial transfer was observed in vivo in an NSG immunodeficient mouse xenograft model and also occurred in human leukemia initiating cells and progenitors.

TL;DR: This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for AML focuses on the management of AML and provides recommendations on the workup, diagnostic evaluation and treatment options for younger and older adult patients.

TL;DR: Overall and relapse-free survival in the present study compared favorably to reports in comparable patient populations and it is concluded that IPH2101 administration is safe and can block KIR for prolonged periods of time with limited side effects.