T
Tiago Ferreira
Researcher at Howard Hughes Medical Institute
Publications - 28
Citations - 4602
Tiago Ferreira is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Biological neural network & Asparagine. The author has an hindex of 15, co-authored 27 publications receiving 3400 citations. Previous affiliations of Tiago Ferreira include McGill University & McGill University Health Centre.
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Journal ArticleDOI
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Rosa C. Paolicelli,Giulia Bolasco,Francesca Pagani,Laura Maggi,Maria Scianni,Patrizia Panzanelli,Maurizio Giustetto,Tiago Ferreira,Eva Guiducci,Laura Dumas,Davide Ragozzino,Cornelius Gross +11 more
TL;DR: It is shown that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice and this work suggests that deficits in microglian function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.
Journal ArticleDOI
Neuronal morphometry directly from bitmap images
Tiago Ferreira,Arne V. Blackman,Julia Oyrer,Sriram Jayabal,Andrew J. Chung,Alanna J. Watt,P. Jesper Sjöström,P. Jesper Sjöström,Donald J van Meyel,Donald J van Meyel +9 more
TL;DR: The use of the Sholl Analysis software to quantify arborization directly from bitmap images correctly identified 80–86% of cells, and the utility of the method in tackling neurons that are particularly slow to reconstruct manually was explored.
Journal ArticleDOI
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain
Johan Winnubst,Erhan Bas,Tiago Ferreira,Zhuhao Wu,Michael N. Economo,Patrick Edson,Ben J. Arthur,Christopher M. Bruns,Konrad Rokicki,David Schauder,Donald J. Olbris,Sean D. Murphy,David G. Ackerman,Cameron Arshadi,Perry Baldwin,Regina Blake,Ahmad Elsayed,Mashtura Hasan,Daniel Ramirez,Bruno Dos Santos,Monet Weldon,Amina Zafar,Joshua T. Dudman,Charles R. Gerfen,Adam W. Hantman,Wyatt Korff,Scott M. Sternson,Nelson Spruston,Karel Svoboda,Jayaram Chandrashekar +29 more
TL;DR: A robust and efficient platform for imaging and reconstructing complete neuronal morphologies, including axonal arbors that span substantial portions of the brain are presented and axonal shapes revealed previously unknown subtypes of projection neurons and suggest organizational principles of long-range connectivity.
Journal ArticleDOI
SNT: a unifying toolbox for quantification of neuronal anatomy
Cameron Arshadi,Ulrik Günther,Mark Eddison,Kyle Harrington,Kyle Harrington,Kyle Harrington,Tiago Ferreira +6 more
TL;DR: SNT as discussed by the authors is an end-to-end framework for neuronal morphometry and whole-brain connectomics that supports tracing, proof-editing, visualization, quantification and modeling of neuroanatomy.
Posted ContentDOI
SNT: A Unifying Toolbox for Quantification of Neuronal Anatomy
TL;DR: SNT is a unifying framework for neuronal morphometry and analysis of single-cell connectomics for the widely used Fiji and ImageJ platforms and establishes an end-to-end platform for tracing, proof-editing, visualization, quantification, and modeling of neuroanatomy.