S
Sung Suk Chae
Researcher at University of Connecticut Health Center
Publications - 6
Citations - 2512
Sung Suk Chae is an academic researcher from University of Connecticut Health Center. The author has contributed to research in topics: G protein-coupled receptor & S1PR1. The author has an hindex of 6, co-authored 6 publications receiving 2398 citations. Previous affiliations of Sung Suk Chae include University of Connecticut & Harvard University.
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Journal ArticleDOI
Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
Yujing Liu,Ryuichi Wada,Tadashi Yamashita,Yide Mi,Chu-Xia Deng,John P. Hobson,Hans M. Rosenfeldt,Victor E. Nava,Sung Suk Chae,Menq Jer Lee,Catherine H. Liu,Timothy Hla,Sarah Spiegel,Richard L. Proia +13 more
TL;DR: The data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development.
Journal ArticleDOI
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
Jihye Paik,Zhihu Ding,Rujuta Narurkar,Shakti Ramkissoon,Florian L. Muller,Walid S. Kamoun,Sung Suk Chae,Hongwu Zheng,Haoqiang Ying,Jed Mahoney,David Hiller,Shan Jiang,Alexei Protopopov,Wing Hung Wong,Lynda Chin,Keith L. Ligon,Ronald A. DePinho +16 more
TL;DR: It is shown that the FoxO family plays a prominent role in NSC proliferation and renewal and coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain.
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Extracellular Export of Sphingosine Kinase-1 Enzyme SPHINGOSINE 1-PHOSPHATE GENERATION AND THE INDUCTION OF ANGIOGENIC VASCULAR MATURATION
Nicolas Ancellin,Chantal Colmont,Joseph Su,Qin Li,Nanette Mittereder,Sung Suk Chae,Steingrimur Stefansson,Gene Liau,Timothy Hla +8 more
TL;DR: Overexpression of SK-1 resulted in enhanced release of SK activity and induced angiogenesis and vascular maturation, suggesting that S1P is made in the extracellular milieu and thatextracellular export of SK contributes to the action of S1p in the vascular system.
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Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
Menq Jer Lee,Shobha Thangada,Jihye Paik,Gopal P. Sapkota,Nicolas Ancellin,Sung Suk Chae,Ming-Tao Wu,Manuel Morales-Ruiz,William C. Sessa,Dario R. Alessi,Timothy Hla +10 more
TL;DR: It is shown that sphingosine-1-phosphate (S1P)-induced endothelial cell migration requires the Akt-mediated phosphorylation of the G protein-coupled receptor (GPCR) EDG-1.
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Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins
TL;DR: The results suggest that endothelial differentiation gene receptor-mediated Rho signaling is required for the activation of integrin αvβ3 as well as β1-containing integrins, leading to the formation of initial focal contacts and endothelial cell migration.