T
Timothy J. Brennan
Researcher at University of Iowa
Publications - 162
Citations - 10877
Timothy J. Brennan is an academic researcher from University of Iowa. The author has contributed to research in topics: Hyperalgesia & Spinal cord. The author has an hindex of 50, co-authored 161 publications receiving 9742 citations. Previous affiliations of Timothy J. Brennan include Food and Drug Administration & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
Management of postoperative pain: A clinical practice guideline from the american pain society, the american society of regional anesthesia and pain medicine, and the american society of anesthesiologists' committee on regional anesthesia, executive committee, and administrative council.
Roger Chou,Debra B. Gordon,Oscar A. de Leon-Casasola,Jack M. Rosenberg,Stephen W. Bickler,Timothy J. Brennan,Todd Carter,Carla L. Cassidy,Eva Chittenden,Ernest Degenhardt,Scott R. Griffith,Renee C.B. Manworren,Bill McCarberg,Robert R. Montgomery,Jamie D. Murphy,Melissa F. Perkal,Santhanam Suresh,Kathleen A. Sluka,Scott A. Strassels,Richard C. Thirlby,Eugene R. Viscusi,Gary A. Walco,Lisa Warner,Steven J. Weisman,Christopher L. Wu +24 more
TL;DR: The American Pain Society, with input from the American Society of Anesthesiologists, developed a clinical practice guideline to promote evidence-based, effective, and safer postoperative pain management in children and adults.
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Characterization of a rat model of incisional pain
TL;DR: The results of tests for withdrawal responses and scores based on weight bearing suggest that a surgical incision of the rat foot causes a reliable and quantifiable mechanical hyperalgesia lasting for several days after surgery.
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The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
Margaret P. Price,Sabrina L. McIlwrath,Jinghui Xie,Chun Cheng,Jing Qiao,Deirdre E. Tarr,Kathleen A. Sluka,Timothy J. Brennan,Gary R. Lewin,Michael J. Welsh,Michael J. Welsh +10 more
TL;DR: The data suggest that DRASic subunits participate in heteromultimeric channel complexes in sensory neurons, and in different cellular contexts, DRASIC may respond to mechanical stimuli or to low pH to mediate normal touch and pain sensation.
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The mammalian sodium channel BNC1 is required for normal touch sensation.
Margaret P. Price,Gary R. Lewin,Sabrina L. McIlwrath,Chun Cheng,Jinghui Xie,Paul A. Heppenstall,Cheryl L. Stucky,Annne G. Mannsfeldt,Timothy J. Brennan,Heather A. Drummond,Jing Qiao,Christopher J. Benson,Delrdre E. Tarr,Ron F. Hrstka,Baoli Yang,Roger A. Williamson,Michael J. Welsh +16 more
TL;DR: It is shown that disrupting the mouse BNC1 gene markedly reduces the sensitivity of a specific component of mechanosensation: low-threshold rapidly adapting mechanoreceptors, and this data identify the B NC1 channel as essential for the normal detection of light touch and indicate that BNC 1 may be a central component of a mechanosensory complex.
Journal ArticleDOI
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
Michael F. Jarvis,Edward C. Burgard,Steve McGaraughty,Prisca Honore,Kevin R. Lynch,Timothy J. Brennan,Alberto Subieta,Tim van Biesen,Jayne Cartmell,Bruce R. Bianchi,Wende Niforatos,Karen Kage,Haixia Yu,Joe Mikusa,Carol T. Wismer,Chang Z. Zhu,Katharine L. Chu,Chih-Hung Lee,Andrew O. Stewart,James S. Polakowski,Bryan F. Cox,Elizabeth A. Kowaluk,Michael Williams,James A. Sullivan,Connie R. Faltynek +24 more
TL;DR: The present data indicate that a potent and selective antagonist of P 2X3 and P2X2/3 receptors effectively reduces both nerve injury and chronic inflammatory nociception, but P2x3 andP2X 2/3 receptor activation may not be a major mediator of acute, acute inflammatory, or visceral pain.