Timothy K. Soh

TL;DR: It is shown that to enter a cell, the virus requires a second receptor, this one inside the infected cell, which sheds light on the “enigmatic resistance” of bird cells to Lassa virus, and the resistance of Lamp1-deficient mice to Lasso virus highlights the relevance of this receptor switch in vivo.

TL;DR: These results define tools for studying the intracellular trafficking of pathogens elicited by inhibition of PIKfyve kinase and suggest the potential for targeting this kinase in developing small-molecule antivirals against SARS-CoV-2.

TL;DR: It is found that the brain parenchyma has a functional type I interferon (IFN) response that can limit VSV spread at both the inoculation site and among synaptically connected neurons.

TL;DR: New tools for studying the intracellular trafficking of pathogens elicited by inhibition of PIKfyve kinase are defined and the potential for targeting this kinase in developing small-molecule antivirals against SARS-CoV-2 is suggested.

TL;DR: In this article, small molecule inhibitors of the main endosomal Phosphatidylinositol-3-Phosphate/Phosphatide 5-Kinase, PIKfyve, have been shown to have potent inhibitory effects on content release and infection by chimeric VSV containing the envelope proteins of Zaire ebolavirus (VSV-ZEBOV) or SARS-CoV-2, elicited by Apilimod and Vacuolin-1.