T
Timothy R. Peterson
Researcher at Massachusetts Institute of Technology
Publications - 10
Citations - 5799
Timothy R. Peterson is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: mTORC1 & Protein kinase B. The author has an hindex of 8, co-authored 10 publications receiving 5265 citations.
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Journal ArticleDOI
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Yasemin Sancak,Timothy R. Peterson,Yoav D. Shaul,Robert A. Lindquist,Carson C. Thoreen,Liron Bar-Peled,David M. Sabatini,David M. Sabatini +7 more
TL;DR: It is found that the Rag proteins—a family of four related small guanosine triphosphatases (GTPases)—interact with mTORC1 in an amino acid–sensitive manner and are necessary for the activation of the m TORC1 pathway by amino acids.
Journal ArticleDOI
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Yasemin Sancak,Carson C. Thoreen,Timothy R. Peterson,Robert A. Lindquist,Seong A. Kang,Eric Spooner,Steven A. Carr,David M. Sabatini,David M. Sabatini +8 more
TL;DR: It is proposed that the relative strengths of the rheb- and PRAS40-mediated inputs to m TORC1 set overall pathway activity and that insulin activates mTORC1 through the coordinated regulation of both.
Journal ArticleDOI
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson,Mathieu Laplante,Carson C. Thoreen,Yasemin Sancak,Seong A. Kang,W. Michael Kuehl,Nathanael S. Gray,David M. Sabatini +7 more
TL;DR: A novel mTOR-interacting protein whose deregulated overexpression in multiple myeloma cells represents a mechanism for activating PI3K/Akt signaling and promoting cell survival.
Journal ArticleDOI
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
TL;DR: The findings reveal that m TORC1 is a key regulator of PPARα function and hepatic ketogenesis and suggest a role for mTORC1 activity in promoting the ageing of the liver.
Journal ArticleDOI
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
Kıvanç Birsoy,Timothy C. Wang,Richard Possemato,Ömer H. Yilmaz,Catherine E Koch,Walter W. Chen,Amanda W. Hutchins,Yetis Gultekin,Timothy R. Peterson,Jan E. Carette,Jan E. Carette,Thijn R Brummelkamp,Thijn R Brummelkamp,Clary B. Clish,David M. Sabatini +14 more
TL;DR: A genome-wide haploid genetic screen is performed to identify resistance mechanisms to 3-bromopyruvate (3-BrPA), a drug candidate that inhibits glycolysis in a poorly understood fashion and identifies the SLC16A1 gene product, MCT1, as the main determinant of 3- BrPA sensitivity.