S
Stephanie Fischinger
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 26
Citations - 1891
Stephanie Fischinger is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Antibody & Immune system. The author has an hindex of 12, co-authored 26 publications receiving 910 citations. Previous affiliations of Stephanie Fischinger include University of Duisburg-Essen & Massachusetts Institute of Technology.
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Journal ArticleDOI
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.
Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,Tomer Zohar,Tomer Zohar,Matthew D. Slein,John F. Burke,Carolin Loos,Carolin Loos,Denise J. McCulloch,Kira L. Newman,Caitlin R Wolf,Jingyou Yu,Kiel Shuey,Jared Feldman,Blake M. Hauser,Timothy M. Caradonna,Aaron G. Schmidt,Todd J. Suscovich,Caitlyn Linde,Yongfei Cai,Dan H. Barouch,Edward T. Ryan,Richelle C. Charles,Douglas A. Lauffenburger,Helen Y. Chu,Galit Alter +27 more
TL;DR: It is demonstrated that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies, point to differences in disease trajectory, highlighting the potential importance of functional antigen- specific humoral immunity to guide patient care and vaccine development.
Journal ArticleDOI
Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses.
Lael M. Yonker,Anne M. Neilan,Yannic C. Bartsch,Ankit B. Patel,James Regan,Puneeta Arya,Elizabeth Gootkind,Grace Park,Margot Hardcastle,Anita St. John,Lori Appleman,Michelle L. Chiu,Allison Fialkowski,Denis De la Flor,Rosiane Lima,Evan A. Bordt,Laura J. Yockey,Paolo D'Avino,Stephanie Fischinger,Jessica E. Shui,Paul H. Lerou,Joseph V. Bonventre,Xu G. Yu,Edward T. Ryan,Ingrid V. Bassett,Daniel Irimia,Andrea G. Edlow,Galit Alter,Jonathan Z. Li,Alessio Fasano +29 more
TL;DR: For example, this article found that children may be a potential source of contagion in the SARS-CoV-2 pandemic despite having milder disease or a lack of symptoms; immune dysregulation is implicated in severe postinfectious MIS-C.
Journal ArticleDOI
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity.
Prabhu S. Arunachalam,Alexandra C. Walls,Nadia A. Golden,Caroline Atyeo,Stephanie Fischinger,Chunfeng Li,Pyone P. Aye,Mary Jane Navarro,Lilin Lai,Venkata Viswanadh Edara,Katharina Röltgen,Kenneth A. Rogers,Lisa Shirreff,Douglas E. Ferrell,Samuel Wrenn,Deleah Pettie,John C. Kraft,Marcos C. Miranda,Elizabeth Kepl,Claire Sydeman,Natalie Brunette,Michael E. P. Murphy,Brooke Fiala,Lauren Carter,Alexander G. White,Meera Trisal,Ching-Lin Hsieh,Kasi E. Russell-Lodrigue,Christopher Monjure,Jason Dufour,Skye Spencer,Lara A. Doyle-Meyers,Rudolph Bohm,Nicholas J. Maness,Chad J. Roy,Jessica A. Plante,Kenneth S. Plante,Alex Lee Zhu,Matthew J. Gorman,Sally Shin,Xiaoying Shen,Jane Fontenot,Shakti Gupta,Derek T. O'Hagan,Robbert van der Most,Rino Rappuoli,Robert L. Coffman,David Novack,Jason S. McLellan,Shankar Subramaniam,David C. Montefiori,Scott D. Boyd,JoAnne L. Flynn,Galit Alter,Francois Villinger,Harry Kleanthous,Jay Rappaport,Mehul S. Suthar,Neil P. King,Neil P. King,David Veesler,Bali Pulendran +61 more
TL;DR: In this article, the authors demonstrate the capacity of a subunit vaccine, comprising the SARS-CoV-2 spike protein receptor-binding domain displayed on an I53-50 protein nanoparticle scaffold (hereafter designated RBD-NP), to stimulate robust and durable neutralizing-antibody responses.
Journal ArticleDOI
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production.
Yuezhou Chen,Adam Zuiani,Stephanie Fischinger,Jyotsna Mullur,Caroline Atyeo,Meghan Travers,Felipe J.N. Lelis,Krista M. Pullen,Hannah Martin,Pei Tong,Avneesh Gautam,Shaghayegh Habibi,Jillian C. Bensko,Deborah Gakpo,Jared Feldman,Blake M. Hauser,Timothy M. Caradonna,Yongfei Cai,John S. Burke,Junrui Lin,James A. Lederer,Evan C. Lam,Christy L. Lavine,Michael S. Seaman,Bing Chen,Bing Chen,Aaron G. Schmidt,Alejandro B. Balazs,Douglas A. Lauffenburger,Galit Alter,Duane R. Wesemann +30 more
TL;DR: Detailed longitudinal antibody responses to SARS-CoV-2 in 92 subjects after symptomatic COVID-19 illuminated an efficient immune phenotype that connects rapid symptom clearance to differential antibody durability dynamics.
Journal ArticleDOI
Compromised SARS-CoV-2-specific placental antibody transfer.
Caroline Atyeo,Caroline Atyeo,Krista M. Pullen,Evan A. Bordt,Stephanie Fischinger,Stephanie Fischinger,John F. Burke,Ashlin R. Michell,Matthew D. Slein,Carolin Loos,Carolin Loos,Lydia L. Shook,Adeline A. Boatin,Laura J. Yockey,David Pépin,Marie-Charlotte Meinsohn,Ngoc Minh Phuong Nguyen,Maeva Chauvin,Drucilla J. Roberts,Ilona T. Goldfarb,Juan D. Matute,Kaitlyn E. James,Lael M. Yonker,Lisa M. Bebell,Anjali J Kaimal,Kathryn J. Gray,Douglas A. Lauffenburger,Andrea G. Edlow,Galit Alter +28 more
TL;DR: Systems serology characterized the Fc-profile of influenza, pertussis, and SARS-CoV-2-specific antibodies transferred across the placenta to point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design.