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Timothy Semple
Researcher at Peter MacCallum Cancer Centre
Publications - 40
Citations - 3130
Timothy Semple is an academic researcher from Peter MacCallum Cancer Centre. The author has contributed to research in topics: T cell & Glomerulonephritis. The author has an hindex of 22, co-authored 37 publications receiving 2441 citations. Previous affiliations of Timothy Semple include Monash University & Monash Medical Centre.
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Journal ArticleDOI
Whole-genome characterization of chemoresistant ovarian cancer
Ann-Marie Patch,Ann-Marie Patch,Elizabeth L. Christie,Dariush Etemadmoghadam,Dariush Etemadmoghadam,Dale W. Garsed,Joshy George,Sian Fereday,Katia Nones,Katia Nones,Prue A. Cowin,Kathryn Alsop,Peter Bailey,Peter Bailey,Karin S. Kassahn,Karin S. Kassahn,Felicity Newell,Michael C.J. Quinn,Michael C.J. Quinn,Stephen H. Kazakoff,Stephen H. Kazakoff,Kelly Quek,Charlotte Wilhelm-Benartzi,Edward Curry,Huei San Leong,Anne Hamilton,Anne Hamilton,Anne Hamilton,Linda Mileshkin,George Au-Yeung,Catherine Kennedy,Jillian Hung,Yoke Eng Chiew,Paul R. Harnett,Michael Friedlander,Michael C. J. Quinn,Jan Pyman,Stephen Cordner,Patricia C. M. O’Brien,Jodie Leditschke,Greg Young,Kate Strachan,Paul Waring,Walid J Azar,Chris Mitchell,Nadia Traficante,Joy Hendley,Heather Thorne,Mark Shackleton,David Miller,Gisela Mir Arnau,Richard W. Tothill,Timothy P. Holloway,Timothy Semple,Ivon Harliwong,Craig Nourse,Ehsan Nourbakhsh,Suzanne Manning,Senel Idrisoglu,Timothy J. C. Bruxner,Angelika N. Christ,Barsha Poudel,Oliver Holmes,Oliver Holmes,Matthew J. Anderson,Conrad Leonard,Conrad Leonard,Andrew Lonie,Nathan E. Hall,Scott Wood,Scott Wood,Darrin Taylor,Qinying Xu,Qinying Xu,J. Lynn Fink,Nick Waddell,Ronny Drapkin,Euan A. Stronach,Hani Gabra,Robert S. Brown,A. Jewell,Shivashankar H. Nagaraj,Emma Markham,Peter Wilson,Jason Ellul,Orla McNally,Maria A. Doyle,Ravikiran Vedururu,Collin Stewart,Ernst Lengyel,John V. Pearson,John V. Pearson,Nicola Waddell,Nicola Waddell,Anna deFazio,Sean M. Grimmond,Sean M. Grimmond,David D.L. Bowtell,David D.L. Bowtell,David D.L. Bowtell +99 more
TL;DR: It is shown that gene breakage commonly inactivates the tumour suppressors RB1, NF1, RAD51B and PTEN in HGSC, and contributes to acquired chemotherapy resistance.
Journal ArticleDOI
UV-associated mutations underlie the etiology of MCV-negative Merkel cell carcinomas
Stephen Q. Wong,Kelly Waldeck,Ismael A. Vergara,Jan Schröder,Jan Schröder,Jan Schröder,Jason Madore,James S. Wilmott,Andrew J. Colebatch,Andrew J. Colebatch,Ricardo De Paoli-Iseppi,Jason Li,Richard Lupat,Timothy Semple,Gisela Mir Arnau,Andrew Fellowes,J. Helen Leonard,George Hruby,Graham J. Mann,John F. Thompson,Carleen Cullinane,Meredith L Johnston,Mark Shackleton,Mark Shackleton,Shahneen Sandhu,Shahneen Sandhu,David D.L. Bowtell,David D.L. Bowtell,Ricky W. Johnstone,Ricky W. Johnstone,Stephen B. Fox,Stephen B. Fox,Grant A. McArthur,Grant A. McArthur,Anthony T. Papenfuss,Richard A. Scolyer,Anthony J. Gill,Rodney J. Hicks,Rodney J. Hicks,Richard W. Tothill,Richard W. Tothill +40 more
TL;DR: Target capture and massively parallel DNA sequencing of 619 cancer genes are performed to provide new insights into the underlying biology of viral-negative MCC and pave the road for further investigation into new treatment opportunities.
Journal ArticleDOI
Th1 and Th17 Cells Induce Proliferative Glomerulonephritis
Shaun A. Summers,Oliver M. Steinmetz,Ming Li,Joshua Y. Kausman,Timothy Semple,Kristy L. Edgtton,Dorin-Bogdan Borza,Hal Braley,Stephen R. Holdsworth,A. Richard Kitching +9 more
TL;DR: Th1 and Th17 effector cells can induce glomerular injury and understanding how these two subsets mediate proliferative forms of glomerulonephritis may lead to targeted therapies.
Journal ArticleDOI
Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary.
Richard W. Tothill,Richard W. Tothill,Jason Li,Linda Mileshkin,Linda Mileshkin,Ken Doig,Terence Siganakis,Prue A. Cowin,Andrew Fellowes,Timothy Semple,Stephen B. Fox,Keith Byron,Adam Kowalczyk,David Thomas,Penelope Schofield,David D.L. Bowtell +15 more
TL;DR: Massively‐parallel DNA sequencing can provide comprehensive mutation, DNA copy‐number, and mutational signature data that are of significant clinical value for a majority of CUP patients, providing both cumulative evidence for the diagnosis of primary site and options for future treatment.
Journal ArticleDOI
The molecular origin and taxonomy of mucinous ovarian carcinoma
Dane Cheasley,Matthew Wakefield,Matthew Wakefield,Georgina L Ryland,Prue E. Allan,Kathryn Alsop,Kathryn Alsop,Kaushalya C. Amarasinghe,Sumitra Ananda,Michael S. Anglesio,George Au-Yeung,George Au-Yeung,Maret Böhm,David D.L. Bowtell,David D.L. Bowtell,Alison Brand,Georgia Chenevix-Trench,Michael Christie,Michael Christie,Yoke Eng Chiew,Michael Churchman,Anna deFazio,Renee Demeo,Rhiannon Dudley,Nicole Fairweather,Clare G Fedele,Clare G Fedele,Sian Fereday,Sian Fereday,Stephen B. Fox,Stephen B. Fox,C. Blake Gilks,Charlie Gourley,Neville F. Hacker,Alison Maree Hadley,Joy Hendley,Gwo-Yaw Ho,Siobhan Hughes,David G. Hunstman,Sally M Hunter,Tom Jobling,Kimberly R. Kalli,Scott H. Kaufmann,Catherine J. Kennedy,Martin Köbel,Cécile Le Page,Jason Li,Richard Lupat,Orla McNally,Jessica N. McAlpine,Anne Marie Mes-Masson,Linda Mileshkin,Diane Provencher,Jan Pyman,Kurosh Rahimi,Simone M Rowley,Carolina Salazar,Goli Samimi,Hugo Saunders,Timothy Semple,Ragwha Sharma,Ragwha Sharma,Alice J. Sharpe,Andrew N. Stephens,Niko Thio,Michelle C. Torres,Nadia Traficante,Nadia Traficante,Zhongyue Xing,Magnus Zethoven,Yoland Antill,Clare L. Scott,Ian G. Campbell,Ian G. Campbell,Kylie L. Gorringe,Kylie L. Gorringe +75 more
TL;DR: It is shown that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC, and high copy number aberration burden is associated with worse prognosis in MOC.