J
Jan Pyman
Researcher at Royal Women's Hospital
Publications - 34
Citations - 2967
Jan Pyman is an academic researcher from Royal Women's Hospital. The author has contributed to research in topics: Ovarian cancer & Cervical intraepithelial neoplasia. The author has an hindex of 17, co-authored 32 publications receiving 2179 citations. Previous affiliations of Jan Pyman include Royal Children's Hospital.
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Journal ArticleDOI
Whole-genome characterization of chemoresistant ovarian cancer
Ann-Marie Patch,Ann-Marie Patch,Elizabeth L. Christie,Dariush Etemadmoghadam,Dariush Etemadmoghadam,Dale W. Garsed,Joshy George,Sian Fereday,Katia Nones,Katia Nones,Prue A. Cowin,Kathryn Alsop,Peter Bailey,Peter Bailey,Karin S. Kassahn,Karin S. Kassahn,Felicity Newell,Michael C.J. Quinn,Michael C.J. Quinn,Stephen H. Kazakoff,Stephen H. Kazakoff,Kelly Quek,Charlotte Wilhelm-Benartzi,Edward Curry,Huei San Leong,Anne Hamilton,Anne Hamilton,Anne Hamilton,Linda Mileshkin,George Au-Yeung,Catherine Kennedy,Jillian Hung,Yoke Eng Chiew,Paul R. Harnett,Michael Friedlander,Michael C. J. Quinn,Jan Pyman,Stephen Cordner,Patricia C. M. O’Brien,Jodie Leditschke,Greg Young,Kate Strachan,Paul Waring,Walid J Azar,Chris Mitchell,Nadia Traficante,Joy Hendley,Heather Thorne,Mark Shackleton,David Miller,Gisela Mir Arnau,Richard W. Tothill,Timothy P. Holloway,Timothy Semple,Ivon Harliwong,Craig Nourse,Ehsan Nourbakhsh,Suzanne Manning,Senel Idrisoglu,Timothy J. C. Bruxner,Angelika N. Christ,Barsha Poudel,Oliver Holmes,Oliver Holmes,Matthew J. Anderson,Conrad Leonard,Conrad Leonard,Andrew Lonie,Nathan E. Hall,Scott Wood,Scott Wood,Darrin Taylor,Qinying Xu,Qinying Xu,J. Lynn Fink,Nick Waddell,Ronny Drapkin,Euan A. Stronach,Hani Gabra,Robert S. Brown,A. Jewell,Shivashankar H. Nagaraj,Emma Markham,Peter Wilson,Jason Ellul,Orla McNally,Maria A. Doyle,Ravikiran Vedururu,Collin Stewart,Ernst Lengyel,John V. Pearson,John V. Pearson,Nicola Waddell,Nicola Waddell,Anna deFazio,Sean M. Grimmond,Sean M. Grimmond,David D.L. Bowtell,David D.L. Bowtell,David D.L. Bowtell +99 more
TL;DR: It is shown that gene breakage commonly inactivates the tumour suppressors RB1, NF1, RAD51B and PTEN in HGSC, and contributes to acquired chemotherapy resistance.
Journal ArticleDOI
Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial
Stephanie M. de Boer,Melanie E Powell,Linda Mileshkin,Dionyssios Katsaros,Paul Bessette,Christine Haie-Meder,Petronella B. Ottevanger,Jonathan A. Ledermann,Pearly Khaw,Alessandro Colombo,Anthony Fyles,Marie Helene Baron,Ina M. Jürgenliemk-Schulz,Henry C Kitchener,Hans W. Nijman,G. Wilson,Susan Brooks,Silvestro Carinelli,Diane Provencher,Chantal Hanzen,Ludy C.H.W. Lutgens,Vincent T.H.B.M. Smit,Naveena Singh,V. Do,Romerai D'Amico,Remi A. Nout,Amanda Feeney,Karen W Verhoeven-Adema,Hein Putter,Carien L. Creutzberg,Mary McCormack,Karen Whitmarsh,Rozenn Allerton,Deborah Gregory,P. Symonds,Peter Hoskin,Madhavi Adusumalli,Anjana Anand,Robert Wade,Alexandra J. Stewart,Wendy Taylor,Roy F.P.M. Kruitwagen,Harry Hollema,Elizabeth Pras,An Snyers,Lukas J.A. Stalpers,Jan J. Jobsen,Annerie Slot,Jan Willem M. Mens,Tanja C. Stam,Baukelien Van Triest,Elzbieta M. Van der Steen Banasik,Karin A.J. De Winter,Michael A. Quinn,Ilka Kolodziej,Jan Pyman,Carol Johnson,Anne Capp,Roldano Fossati,Sergio Gribaudo,Andrea Lissoni,Annamaria Ferrero,Grazia Artioli,Cathy Davidson,C. Meg McLachlin,Prafull Ghatage,Paula V.C. Rittenberg,Luis Souhami,Gillian Thomas,Pierre Duvillard,Dominique Berton-Rigaud,Nicole Tubiana-Mathieu +71 more
TL;DR: Adjuvant chemotherapy given during and after radiotherapy for high-risk endometrial cancer did not improve 5-year overall survival, although it did increase failure-free survival.
Journal ArticleDOI
Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial
Stephanie M. de Boer,Melanie E Powell,Linda Mileshkin,Dionyssios Katsaros,Paul Bessette,Christine Haie-Meder,Petronella B. Ottevanger,Jonathan A. Ledermann,Pearly Khaw,Romerai D'Amico,Anthony Fyles,Marie-Helene Baron,Ina M. Jürgenliemk-Schulz,Henry C Kitchener,Hans W. Nijman,G. Wilson,Susan Brooks,Sergio Gribaudo,Diane Provencher,Chantal Hanzen,Roy F.P.M. Kruitwagen,Vincent T.H.B.M. Smit,Naveena Singh,V. Do,Andrea Lissoni,Remi A. Nout,Amanda Feeney,Karen W Verhoeven-Adema,Hein Putter,Carien L. Creutzberg,M McCormack,K Whitmarsh,R Allerton,Deborah Gregory,P. Symonds,Peter Hoskin,M Adusumalli,Anjana Anand,R Wade,Alexandra J. Stewart,W Taylor,L.C.H.W. Lutgens,Harmen Hollema,Elisabeth Pras,An Snyers,GH Westerveld,J.J. Jobsen,Annerie Slot,J.W.M. Mens,Tanja C. Stam,B. van Triest,E. Van der Steen-Banasik,Kaj De Winter,Michael A. Quinn,Ilka Kolodziej,Jan Pyman,Colin D. Johnson,Anne Capp,Roldano Fossati,Alessandro Colombo,Silvestro Carinelli,Annamaria Ferrero,G Artioli,C Davidson,C M McLachlin,Prafull Ghatage,Pvc Rittenberg,Luis Souhami,Gillian Thomas,Pierre Duvillard,Dominique Berton-Rigaud,Nicole Tubiana-Mathieu +71 more
TL;DR: The PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy versus pelvic radiotherapy alone for women with high-risk endometrial cancer and did a post-hoc survival analysis to investigate patterns of recurrence.
Journal ArticleDOI
Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors
Ardian Latifi,Rodney B. Luwor,Maree Bilandzic,Simon Nazaretian,Kaye L. Stenvers,Jan Pyman,Hong-Jian Zhu,Erik W. Thompson,Michael A. Quinn,Michael A. Quinn,Jock K. Findlay,Jock K. Findlay,Nuzhat Ahmed +12 more
TL;DR: Using a novel purification method, a distinct separation of ascites cells into epithelial tumorigenic and mesenchymal non-tumorigenic populations is demonstrated for the first time and it is demonstrated that cells from the ascites of CR patients are predominantly epithelial and show a trend towards increased mRNA expression of genes associated with CSCs, compared to cells isolated from the Ascites of CN patients.
Journal ArticleDOI
Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts
Monique Topp,Monique Topp,Lynne Hartley,Michele Cook,Valerie Heong,Valerie Heong,Valerie Heong,Emma Boehm,Lauren McShane,Jan Pyman,Orla McNally,Sumitra Ananda,Marisol Harrell,Dariush Etemadmoghadam,Dariush Etemadmoghadam,Laura Galletta,Kathryn Alsop,Gillian Mitchell,Stephen B. Fox,Stephen B. Fox,Jeffrey B. Kerr,Karla J. Hutt,Karla J. Hutt,Scott H. Kaufmann,Elizabeth M. Swisher,David D.L. Bowtell,David D.L. Bowtell,Matthew Wakefield,Matthew Wakefield,Clare L. Scott,Clare L. Scott,Clare L. Scott +31 more
TL;DR: Improvement in the ability to target underlying drivers and vulnerabilities of high‐grade serous ovarian cancer (HG‐SOC) requires the development of molecularly annotated pre‐clinical models reflective of clinical responses.