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Charlotte Wilhelm-Benartzi
Researcher at Cardiff University
Publications - 44
Citations - 3150
Charlotte Wilhelm-Benartzi is an academic researcher from Cardiff University. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 18, co-authored 39 publications receiving 2570 citations. Previous affiliations of Charlotte Wilhelm-Benartzi include Brown University & Imperial College London.
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Journal ArticleDOI
Whole-genome characterization of chemoresistant ovarian cancer
Ann-Marie Patch,Ann-Marie Patch,Elizabeth L. Christie,Dariush Etemadmoghadam,Dariush Etemadmoghadam,Dale W. Garsed,Joshy George,Sian Fereday,Katia Nones,Katia Nones,Prue A. Cowin,Kathryn Alsop,Peter Bailey,Peter Bailey,Karin S. Kassahn,Karin S. Kassahn,Felicity Newell,Michael C.J. Quinn,Michael C.J. Quinn,Stephen H. Kazakoff,Stephen H. Kazakoff,Kelly Quek,Charlotte Wilhelm-Benartzi,Edward Curry,Huei San Leong,Anne Hamilton,Anne Hamilton,Anne Hamilton,Linda Mileshkin,George Au-Yeung,Catherine Kennedy,Jillian Hung,Yoke Eng Chiew,Paul R. Harnett,Michael Friedlander,Michael C. J. Quinn,Jan Pyman,Stephen Cordner,Patricia C. M. O’Brien,Jodie Leditschke,Greg Young,Kate Strachan,Paul Waring,Walid J Azar,Chris Mitchell,Nadia Traficante,Joy Hendley,Heather Thorne,Mark Shackleton,David Miller,Gisela Mir Arnau,Richard W. Tothill,Timothy P. Holloway,Timothy Semple,Ivon Harliwong,Craig Nourse,Ehsan Nourbakhsh,Suzanne Manning,Senel Idrisoglu,Timothy J. C. Bruxner,Angelika N. Christ,Barsha Poudel,Oliver Holmes,Oliver Holmes,Matthew J. Anderson,Conrad Leonard,Conrad Leonard,Andrew Lonie,Nathan E. Hall,Scott Wood,Scott Wood,Darrin Taylor,Qinying Xu,Qinying Xu,J. Lynn Fink,Nick Waddell,Ronny Drapkin,Euan A. Stronach,Hani Gabra,Robert S. Brown,A. Jewell,Shivashankar H. Nagaraj,Emma Markham,Peter Wilson,Jason Ellul,Orla McNally,Maria A. Doyle,Ravikiran Vedururu,Collin Stewart,Ernst Lengyel,John V. Pearson,John V. Pearson,Nicola Waddell,Nicola Waddell,Anna deFazio,Sean M. Grimmond,Sean M. Grimmond,David D.L. Bowtell,David D.L. Bowtell,David D.L. Bowtell +99 more
TL;DR: It is shown that gene breakage commonly inactivates the tumour suppressors RB1, NF1, RAD51B and PTEN in HGSC, and contributes to acquired chemotherapy resistance.
Journal ArticleDOI
Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study
Dominique S. Michaud,Jacques Izard,Charlotte Wilhelm-Benartzi,Doo Ho You,Verena A. Grote,Anne Tjønneland,Christina C. Dahm,Kim Overvad,Mazda Jenab,Veronika Fedirko,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Françoise Clavel-Chapelon,Françoise Clavel-Chapelon,Antoine Racine,Antoine Racine,Rudolf Kaaks,Heiner Boeing,Jana Foerster,Antonia Trichopoulou,Pagona Lagiou,Pagona Lagiou,Pagona Lagiou,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Carlotta Sacerdote,Sabina Sieri,Domenico Palli,Rosario Tumino,Salvatore Panico,Peter D. Siersema,Petra H.M. Peeters,Eiliv Lund,Aurelio Barricarte,José María Huerta,Esther Molina-Montes,Miren Dorronsoro,J. Ramón Quirós,Eric J. Duell,Weimin Ye,Weimin Ye,Malin Sund,Björn Lindkvist,Dorthe Johansen,Kay-Tee Khaw,Nicholas J. Wareham,Ruth C. Travis,Paolo Vineis,H. Bas Bueno-de-Mesquita,Elio Riboli +49 more
TL;DR: Monitoring of antibodies to oral bacteria in prediagnosis blood samples found that increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer.
Journal ArticleDOI
Poised epigenetic states and acquired drug resistance in cancer
TL;DR: Poised epigenetic states in tumour cells may drive multistep epigenetic fixation of gene expression during the acquisition of drug resistance, which has implications for clinical strategies to prevent the emergence ofdrug resistance.
Journal ArticleDOI
Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling
Constanze Zeller,Wei Dai,Nicola Steele,Afshan Siddiq,Andrew Walley,Charlotte Wilhelm-Benartzi,S. Rizzo,A. van der Zee,Jane A. Plumb,Robert S. Brown,Robert S. Brown +10 more
TL;DR: This combined genomics approach has identified further potential key drivers of chemoresistance whose expression is silenced by DNA methylation that should be further evaluated as clinical biomarkers of drug resistance.
Journal ArticleDOI
In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta.
Charlotte Wilhelm-Benartzi,E. Andres Houseman,Matthew A. Maccani,Graham M. Poage,Devin C. Koestler,Scott M. Langevin,Luc Gagne,Carolyn E. Banister,James F. Padbury,Carmen J. Marsit +9 more
TL;DR: The results suggest that repetitive element methylation markers, most notably AluYb8 methylation, may be susceptible to epigenetic alterations resulting from the intrauterine environment and play a critical role in mediating placenta function, and may ultimately inform on the developmental basis of health and disease.