T
Timothy T. Lu
Researcher at University of Kiel
Publications - 38
Citations - 4459
Timothy T. Lu is an academic researcher from University of Kiel. The author has contributed to research in topics: Population & KRAS. The author has an hindex of 25, co-authored 37 publications receiving 4178 citations. Previous affiliations of Timothy T. Lu include San Diego State University & University of California, San Francisco.
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Journal ArticleDOI
Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting
Mathias Ehrich,Cosmin Deciu,Tricia Zwiefelhofer,John A. Tynan,Lesley Cagasan,Roger Chan Tim,Vivian Lu,Ron McCullough,Erin McCarthy,Anders Olof Herman Nygren,Jarrod Dean,Lin Tang,Don Hutchison,Timothy T. Lu,Huiquan Wang,Vach Angkachatchai,Paul Oeth,Charles R. Cantor,Allan T. Bombard,Dirk van den Boom +19 more
TL;DR: Extending the scope of previous reports, this study demonstrates that plasma DNA sequencing is a viable method for noninvasive detection of fetal trisomy 21 and warrants clinical validation in a larger multicenter study.
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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
Stacy L. Musone,Kimberly E. Taylor,Timothy T. Lu,Joanne Nititham,Ricardo C. Ferreira,Ward Ortmann,Nataliya Shifrin,Michelle Petri,M. Ilyas Kamboh,Susan Manzi,Michael F. Seldin,Peter K. Gregersen,Timothy W. Behrens,Averil Ma,Pui-Yan Kwok,Lindsey A. Criswell +15 more
TL;DR: It is shown that three independent SNPs in the TNFAIP3 region are associated with systemic lupus erythematosus among individuals of European ancestry, providing critical links between A20 and the etiology of SLE.
Journal ArticleDOI
Correlation between genetic and geographic structure in Europe.
Oscar Lao,Timothy T. Lu,Michael Nothnagel,Olaf Junge,Sandra Freitag-Wolf,Amke Caliebe,Miroslava Balascakova,Jaume Bertranpetit,Laurence A. Bindoff,David Comas,Gunilla Holmlund,Anastasia Kouvatsi,Milan Macek,Isabelle Mollet,Walther Parson,Jukka U. Palo,Rafał Płoski,Antti Sajantila,Adriano Tagliabracci,Ulrik Gether,Thomas Werge,Fernando Rivadeneira,Albert Hofman,André G. Uitterlinden,Christian Gieger,Heinz Erich Wichmann,Andreas Ruther,Stefan Schreiber,Christian Becker,Peter Nürnberg,Matthew R. Nelson,Michael Krawczak,Manfred Kayser +32 more
TL;DR: Although Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations was investigated, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance, which provided evidence for a spatial continuity of genetic diversity in Europe.
Journal ArticleDOI
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Andre Franke,Tobias Balschun,Tom H. Karlsen,Jürgen Hedderich,Sandra May,Timothy T. Lu,Dörthe Schuldt,Susanna Nikolaus,Philip Rosenstiel,Michael Krawczak,Stefan Schreiber +10 more
TL;DR: Investigating previously reported susceptibility loci in a German sample of individuals with Crohn's disease or ulcerative colitis and healthy controls identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcers.
Journal ArticleDOI
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Stephan Buch,Clemens Schafmayer,Henry Völzke,Christian Becker,Andre Franke,Huberta von Eller-Eberstein,Christian Kluck,Ingelore Bässmann,Mario Brosch,Frank Lammert,Juan Francisco Miquel,Flavio Nervi,Michael Wittig,Dieter Rosskopf,Birgit Timm,Christine Höll,Marcus Seeger,Abdou ElSharawy,Timothy T. Lu,Jan Hendrik Egberts,Fred Fändrich,Ulrich R. Fölsch,Michael Krawczak,Stefan Schreiber,Peter Nürnberg,Jürgen Tepel,Jochen Hampe +26 more
TL;DR: In this article, a follow-up study of the 235 most significant SNPs in 1,105 affected individuals and 873 controls replicated the disease association of SNP A-1791411 in ABCG8 (allelic P value PCCA = 4.1 × 10−9).