M
Mario Brosch
Researcher at Dresden University of Technology
Publications - 47
Citations - 4123
Mario Brosch is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Fatty liver & Single-nucleotide polymorphism. The author has an hindex of 23, co-authored 43 publications receiving 3293 citations. Previous affiliations of Mario Brosch include University of Kiel.
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Journal ArticleDOI
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Simone Wahl,Alexander W. Drong,Benjamin Lehne,Marie Loh,Marie Loh,Marie Loh,William R. Scott,William R. Scott,Sonja Kunze,Pei-Chien Tsai,Janina S. Ried,Weihua Zhang,Weihua Zhang,Youwen Yang,Sili Tan,Giovanni Fiorito,Lude Franke,Simonetta Guarrera,Silva Kasela,Jennifer Kriebel,Rebecca C Richmond,Marco Adamo,Uzma Afzal,Uzma Afzal,Mika Ala-Korpela,Mika Ala-Korpela,Mika Ala-Korpela,Benedetta Albetti,Ole Ammerpohl,Jane F. Apperley,Marian Beekman,Pier Alberto Bertazzi,S. Lucas Black,Christine Blancher,Marc Jan Bonder,Mario Brosch,Maren Carstensen-Kirberg,Anton J. M. de Craen,Simon de Lusignan,Abbas Dehghan,Mohamed Elkalaawy,Krista Fischer,Oscar H. Franco,Tom R. Gaunt,Jochen Hampe,Majid Hashemi,Aaron Isaacs,Andrew Jenkinson,Sujeet Jha,Norihiro Kato,Vittorio Krogh,Michael Laffan,Christa Meisinger,Thomas Meitinger,Zuan Yu Mok,Valeria Motta,Hong Kiat Ng,Zacharoula Nikolakopoulou,Georgios Nteliopoulos,Salvatore Panico,Natalia Pervjakova,Holger Prokisch,Wolfgang Rathmann,Michael Roden,Federica Rota,Michelle Ann Rozario,Johanna K. Sandling,Johanna K. Sandling,Clemens Schafmayer,Katharina Schramm,Reiner Siebert,Reiner Siebert,P. Eline Slagboom,Pasi Soininen,Pasi Soininen,Lisette Stolk,Konstantin Strauch,E-Shyong Tai,Letizia Tarantini,Barbara Thorand,Ettje F. Tigchelaar,Rosario Tumino,André G. Uitterlinden,Cornelia M. van Duijn,Joyce B. J. van Meurs,Paolo Vineis,Ananda R. Wickremasinghe,Cisca Wijmenga,Tsun-Po Yang,Wei Yuan,Wei Yuan,Alexandra Zhernakova,Rachel L. Batterham,George Davey Smith,Panos Deloukas,Panos Deloukas,Panos Deloukas,Bastiaan T. Heijmans,Christian Herder,Albert Hofman,Cecilia M. Lindgren,Cecilia M. Lindgren,Lili Milani,Pim van der Harst,Annette Peters,Thomas Illig,Caroline L Relton,Melanie Waldenberger,Marjo-Riitta Järvelin,Valentina Bollati,Richie Soong,Tim D. Spector,James Scott,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Paul Elliott,Paul Elliott,Jordana T. Bell,Giuseppe Matullo,Christian Gieger,Jaspal S. Kooner,Harald Grallert,John C. Chambers +123 more
TL;DR: In this article, the authors used epigenome-wide association to show that body mass index (BMI), a key measure of adiposity, is associated with widespread changes in DNA methylation.
Journal ArticleDOI
Obesity accelerates epigenetic aging of human liver
Steve Horvath,Wiebke Erhart,Mario Brosch,Ole Ammerpohl,Witigo von Schönfels,M Ahrens,Nils Heits,Jordana T. Bell,Pei-Chien Tsai,Tim D. Spector,Panos Deloukas,Reiner Siebert,Bence Sipos,Thomas Becker,Christoph Röcken,Clemens Schafmayer,Jochen Hampe +16 more
TL;DR: The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer.
Journal ArticleDOI
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Stephan Buch,Felix Stickel,Eric Trepo,Michael J. Way,A Herrmann,Hans Dieter Nischalke,Mario Brosch,Jonas Rosendahl,Thomas Berg,Monika Ridinger,Marcella Rietschel,Andrew McQuillin,Josef Frank,Falk Kiefer,Stefan Schreiber,Wolfgang Lieb,Michael Soyka,Nasser Semmo,Elmar Aigner,Christian Datz,Renate Schmelz,Stefan Brückner,Sebastian Zeissig,Anna-Magdalena Stephan,Norbert Wodarz,Jacques Devière,Nicolas Clumeck,Christoph Sarrazin,Frank Lammert,Thierry Gustot,Pierre Deltenre,Pierre Deltenre,Henry Völzke,Markus M. Lerch,Julia Mayerle,Florian Eyer,Clemens Schafmayer,Sven Cichon,Markus M. Nöthen,Michael Nothnagel,David Ellinghaus,Klaus Huse,Andre Franke,Steffen Zopf,Claus Hellerbrand,Christophe Moreno,Denis Franchimont,Marsha Y. Morgan,Jochen Hampe +48 more
TL;DR: A genome-wide association study for alcohol-related cirrhosis in individuals of European descent with subsequent validation in two independent European cohorts is performed, suggesting that lipid turnover is important in the pathogenesis of alcohol- related Cirrhosis.
Journal ArticleDOI
DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery
M Ahrens,Ole Ammerpohl,Witigo von Schönfels,Julia Kolarova,Susanne Bens,Timo Itzel,Andreas Teufel,A Herrmann,Mario Brosch,Holger Hinrichsen,Wiebke Erhart,Jan Hendrik Egberts,Bence Sipos,Stefan Schreiber,Robert Häsler,Felix Stickel,Thomas Becker,Michael Krawczak,Christoph Röcken,Reiner Siebert,Clemens Schafmayer,Jochen Hampe +21 more
TL;DR: Liver samples from morbidly obese patients with all stages of NAFLD and controls were analyzed by array-based DNA methylation and mRNA expression profiling, providing an example of treatment-induced epigenetic organ remodeling in humans.
Journal ArticleDOI
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Stephan Buch,Clemens Schafmayer,Henry Völzke,Christian Becker,Andre Franke,Huberta von Eller-Eberstein,Christian Kluck,Ingelore Bässmann,Mario Brosch,Frank Lammert,Juan Francisco Miquel,Flavio Nervi,Michael Wittig,Dieter Rosskopf,Birgit Timm,Christine Höll,Marcus Seeger,Abdou ElSharawy,Timothy T. Lu,Jan Hendrik Egberts,Fred Fändrich,Ulrich R. Fölsch,Michael Krawczak,Stefan Schreiber,Peter Nürnberg,Jürgen Tepel,Jochen Hampe +26 more
TL;DR: In this article, a follow-up study of the 235 most significant SNPs in 1,105 affected individuals and 873 controls replicated the disease association of SNP A-1791411 in ABCG8 (allelic P value PCCA = 4.1 × 10−9).