Sandra Freitag-Wolf

TL;DR: In this paper, a modified Ashcroft scale was proposed for the quantification of lung fibrosis in small animals, where the assignment of grades from 0 to 8 was defined for the increasing extent of lung histological samples.

TL;DR: In this paper, the genetic and geographic distance matrices were used to identify two statistically significant barriers for the 23 subpopulations of the Finnish and all other sub-populations.

TL;DR: Although Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations was investigated, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance, which provided evidence for a spatial continuity of genetic diversity in Europe.

TL;DR: Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

TL;DR: Results provide strong evidence that oxidative stress is significantly involved in cartilage degradation in experimental arthritis, and indicate that the presence of a functional Nrf2 gene is a major requirement for limiting cartilage destruction.