Correlation between genetic and geographic structure in Europe.
Oscar Lao,Timothy T. Lu,Michael Nothnagel,Olaf Junge,Sandra Freitag-Wolf,Amke Caliebe,Miroslava Balascakova,Jaume Bertranpetit,Laurence A. Bindoff,David Comas,Gunilla Holmlund,Anastasia Kouvatsi,Milan Macek,Isabelle Mollet,Walther Parson,Jukka U. Palo,Rafał Płoski,Antti Sajantila,Adriano Tagliabracci,Ulrik Gether,Thomas Werge,Fernando Rivadeneira,Albert Hofman,André G. Uitterlinden,Christian Gieger,Heinz Erich Wichmann,Andreas Ruther,Stefan Schreiber,Christian Becker,Peter Nürnberg,Matthew R. Nelson,Michael Krawczak,Manfred Kayser +32 more
TLDR
Although Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations was investigated, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance, which provided evidence for a spatial continuity of genetic diversity in Europe.About:
This article is published in Current Biology.The article was published on 2008-08-26 and is currently open access. It has received 425 citations till now. The article focuses on the topics: Genetic structure & Effective population size.read more
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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
Ancient Admixture in Human History
Nick Patterson,Priya Moorjani,Yontao Luo,Swapan Mallick,Nadin Rohland,Yiping Zhan,Teri Genschoreck,Teresa Webster,David Reich,David Reich +9 more
TL;DR: A suite of methods for learning about population mixtures are presented, implemented in a software package called ADMIXTOOLS, that support formal tests for whether mixture occurred and make it possible to infer proportions and dates of mixture.
Journal ArticleDOI
Genes mirror geography within Europe.
John Novembre,Toby Johnson,Toby Johnson,Katarzyna Bryc,Zoltán Kutalik,Adam R. Boyko,Adam Auton,Amit Indap,Karen S. King,Sven Bergmann,Matthew R. Nelson,Matthew Stephens,Carlos Bustamante +12 more
TL;DR: Despite low average levels of genetic differentiation among Europeans, there is a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans.
Journal ArticleDOI
Reconstructing Indian Population History
TL;DR: It is predicted that there will be an excess of recessive diseases in India, which should be possible to screen and map genetically and is higher in traditionally upper caste and Indo-European speakers.
Journal ArticleDOI
Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study
Andri Rauch,Zoltán Kutalik,Zoltán Kutalik,Patrick Descombes,Tao Cai,Julia di Iulio,Tobias Mueller,Murielle Bochud,Manuel Battegay,Enos Bernasconi,Jan Borovicka,Sara Colombo,Andreas Cerny,Jean-François Dufour,Hansjakob Furrer,Huldrych F. Günthard,Markus H. Heim,Bernard Hirschel,Raffaele Malinverni,Darius Moradpour,Beat Müllhaupt,Andrea Witteck,Jacques S. Beckmann,Jacques S. Beckmann,Thomas Berg,Sven Bergmann,Sven Bergmann,Francesco Negro,Amalio Telenti,Pierre-Yves Bochud +29 more
TL;DR: The association of the IL28B locus with natural and treatment-associated control of HCV indicates the importance of innate immunity and interferon lambda in the pathogenesis ofHCV infection.
References
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